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US 5,492,919 AGranted
5-HT.sub.4 receptor antagonists
AssigneeSmithKline Beecham Corporation
InventorsGareth J. Sanger, Francis D. King, Gordon S. Baxter, Laramie M. Gaster, Alberto J. Kaumann, Guy A. Kennett, Keith R. Mulholland, Mythily Vimal, Kay A. Wardle, Paul A. Wyman, Rodney C. Young
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Abstract
The invention provides the use of a compound of formula (I) ##STR1## wherein A, E, F, U, X, Y, Z, are as defined in the specification, or a pharmaceutically acceptable salt thereof, for the treatment of diarrhea predominant irritable bowel syndrome.
Claims1
A method of treating diarrhea predominant irritable bowel syndrome, which comprises administering a compound selected from:
- 5-[3-(N-methylbutylamino)propyl]-3-[1-methyl-1H-indol-3-yl]-1,2,4-oxadiazol e,
- 5[N-butyl-4-piperidylmethyl]-3-(1-methylindol-3-yl)-1,2,4-oxadiazole, and
- 5[2-((R)-(+)-.alpha.-methylbenzylamino)ethyl]-3-(1-methylindol-3-yl]-1,2,4- oxadiazole.
Dependencies are inferred from the claim text.