Back to results
US 5,492,915 AGranted
Substituted quinolyl compounds exhibiting selective leukotriene B.sub.4 antagonist activity
AssigneeRhone-Poulenc Rorer S.A.
InventorsNorbert Dereu, Wolfram Hendel, Richard Labaudiniere
Life of this patent
Estimating the term…
Abstract
This invention relates to compounds having selective LTB.sub.4 antagonist properties. Therapeutic compositions comprising said compounds and methods for the treatment of disorders involving LTB.sub.4 agonist-mediated activity utilizing said compositions wherein the compounds are described by the formula ##STR1## wherein R.sub.4, X, R, Y, R', Q, m and n are herein defined, and pharmaceutically acceptable salts thereof.
Claims9
A compound of the formula:
- ##STR10## where m is 1-8, n is 0-8 and n+m is 2-8;
- X is S, O, NR', CR'R', CR'.dbd.CR', CO--NR", NR"--CO, CHR'--O or a bond;
- Y is S, O, NR", CR'R', CR'.dbd.CR', CO--NR', NR"--CO, CO or CR'--OH;
- W is CR';
- Z is N;
- R and R' are independently hydrogen or alkyl;
- R" is hydrogen;
- R.sub.1 is phenyl, substituted phenyl or thienyl where the substituents are selected from alkyl, alkoxy, halo, haloalkyl, alkylthio, nitro, amine and mono- or dialkylamino;
- R.sub.2 and R.sub.3 together with the ring to which they are attached form an optionally substituted fused bicyclic ring system where the substituents are selected from alkyl, alkoxy or halo;
- R.sub.4 is R.sub.1, R.sub.1 -loweralkyl- or X.sub.1 --(CH.sub.2 .sub.t --R.sub.1 -- where X.sub.1 is S, O, NR", CR'R' or CO and t is 1-4;
- and
- Q is COOR.sub.6, COOM, CONR.sub.7 R.sub.7, CN, CONHSO.sub.2 R.sub.6, tetrazolyl or tetrazolyl substituted with alkyl, carboxyalkyl or carbalkoxyalkyl and ##STR11## where R.sub.6 is hydrogen, alkyl or aralkyl, R.sub.7 is hydrogen, alkyl, aralkyl or cycloalkyl and M is a metal or ammonia salt;
- or a pharmaceutically acceptable salt thereof.
10 more elements
Dependencies are inferred from the claim text.