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US 5,492,913 AGranted
N-benzylpiperazine compounds
AssigneeAdir et Compagnie
InventorsMichel Wierzbicki, Jean Lepagnol, Jean-Paul Tillement, Bernard Testa, Yves Rolland
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Abstract
The compounds are N-(unsubstituted or substituted) N'-benzylpiperazine compounds and pharmaceutically tolerable salts thereof, useful for treating neuronal disorders resulting from the dysfunctioning of oxidative metabolism. A compound disclosed is: N-ethyl N'-(2-hydroxy-3,4- dimethoxybenzyl)-piperazine and its dihydrochloride.
Claims7
An N-benzylpiperazine compound selected from those of formula I:
- ##STR11## wherein R represents:
- straight-chain or branched alkyl having inclusive 1 to 20 carbon atoms which is optionally mono- or poly-substituted by:
- a. cycloalkyl having 3 to 7 carbon atoms inclusive, unsubstituted or substituted by phenyl which is unsubstituted or substituted by one or more halogen atoms or by alkyl or alkoxy each having 1 to 5 carbon atoms inclusive, or by
- OR.sub.1 in which R.sub.1 represents:
- b. hydrogen or
- straight-chain or branched alkyl having 1 to 5 carbon atoms inclusive;
- and pharmceutically-acceptable acid addition salts thereof.
4 more elements
Dependencies are inferred from the claim text.