Retrocarbamate protease inhibitors

A compound of the formula ##STR43## including a pharmaceutically acceptable salt thereof wherein:

• R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkylene-aryl, and alkylene-substituted aryl;
• R.sub.3 and R.sub.4 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, aryl, substituted aryl, alkylene-aryl, alkylene-substituted aryl, alkylene-cycloalkyl, and alkylene-heterocyclo;
• R.sub.5 is hydrogen, alkyl, substituted alkyl, alkylene-aryl, or alkylene-substituted aryl;
• R.sub.6 and R.sub.7 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkylene-aryl, and alkylene-substituted aryl and R.sub.6 and R.sub.7 taken together with the N-atom to which they are attached complete a heterocyclic ring of 5 to 7 atoms;
• A is hydrogen, alkyl, ##STR44## R.sub.8, R.sub.9 and R.sub.10 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, aryl, substituted aryl, alkylene-cycloalkyl, alkylene-aryl, and alkylene-substituted aryl or R.sub.8 and R.sub.9 join together to complete a carbocyclic ring of 3 to 7 carbon atoms;
• Z is oxygen or sulfur;
• E is a single bond or A--E represents the peptidyl chain ##STR45## a, b, c, and d are each zero or one;
• and R.sub.11, R.sub.12, R.sub.13 and R.sub.14 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkylene-aryl, alkylene-substituted aryl, and alkylene-heterocyclo.