Triazolopyridazine derivatives, their production and use

A compound of the formula:

• ##STR35## wherein R.sup.1 represents (i) a hydrogen atom, (ii) a C.sub.1-6 alkyl group which may have one to four substituents selected from the group consisting of a hydroxyl group, an amino group, a carboxyl group, a nitro group, a mono- or di-C.sub.1-6 alkylamino group, a C.sub.1-6 alkoxy group, a C.sub.1-6 alkyl-carbonyloxy group and a halogen atom or (iii) a halogen atom;
• R.sup.2 and R.sup.3 independently represent a hydrogen atom or a C.sub.1-6 alkyl group which may have one to four substituents selected from the group consisting of a hydroxyl group, an amino group, a carboxyl group, a nitro group, a mono- or di-C.sub.1-6 alkylamino group, a C.sub.1-6 alkoxy group, a C.sub.1-6 alkyl-carbonyloxy group and a halogen atom;
• X represents an oxygen atom, a sulfur atom or a methylene group;
• Y represents (a) a group shown by the formula:
• ##STR36## wherein R.sup.4 and R.sup.5 independently represent a hydrogen atom or a C.sub.1-6 alkyl group which may have one to four substituents selected from the group consisting of a hydroxyl group, an amino group, a carboxyl group, a nitro group, a mono- or di-C.sub.1-6 alkylamino group, a C.sub.1-6 alkoxy group, a C.sub.1-6 alkyl-carbonyloxy group and a halogen atom, or (b) divalent group selected from the group consisting of the formula:
• ##STR37## which may be substituted with one to five substituents selected from the group consisting of (i) a C.sub.1-6 alkyl group which may be substituted with one to four substituents selected from the group consisting of a hydroxyl group, an amino group, a mono- or di-C.sub.1-6 alkylamino group, a C.sub.1-6 alkoxy group, a C.sub.1-6 alkyl-carbonyloxy group and a halogen atom, (ii) an amino group which may be substituted with one to two substituents selected from a C.sub.1-6 alkyl group and a C.sub.1-6 acyl group, or a pyrrolidino, a morpholine, a piperidino or a 1-piperazinyl group, (iii) a hydroxyl group, (iv) a carboxyl group, (v) a nitro group, (vi) a C.sub.1-6 alkoxy group and (vii) a halogen atom;
• R.sup.6 and R.sup.7 independently represent (1) a hydrogen atom, (2) a C.sub.1-6 alkyl group which may have one to four substituents selected from the group consisting of a hydroxyl group, an amino group, a carboxyl group, a nitro group, a mono- or di-C.sub.1-6 alkylamino group, a C.sub.1-6 alkoxy group, a C.sub.1-6 alkyl-carbonyloxy group and a halogen atom, (3) a C.sub.3-6 cycloalkyl group which may be substituted with one to four substituents selected from the group consisting of a hydroxyl group, an amino group, a carboxyl group, a nitro group, a mono- or di-C.sub.1-6 alkylamino group, a C.sub.1-6 alkoxy group, a C.sub.1-6 alkyl-carbonyloxy group and a halogen atom, or (4) a C.sub.6-4 aryl group which may be substituted with one to five substituents selected from the group consisting of (a) a C.sub.1-6 alkyl group which may be substituted with one to four substituents selected from the group consisting of a hydroxyl group, an amino group, a mono-or di-C.sub. 1-6 alkylamino group, a C.sub.1-6 alkoxy group, and a halogen atom, (b) an amino group which may be substituted with one or two C.sub.1-6 alkyl groups, or a pyrrolidino, a morpholino, a piperidino or a 1-piperazinyl group, (c) an acetamido group, (d) a hydroxyl group, (e) a carboxyl group, (f) a nitro group, (g) a C.sub.1-6 alkoxy group, (h) a C.sub.1-6 alkyl-carbonyloxy group and (i) a halogen atom, or (5) R.sup.6 and R.sup.7 together with the adjacent nitrogen atom may form a nitrogen-containing heterocyclic group selected from the group consisting of:
• ##STR38## which may be substituted with one to five substituents selected from the group consisting of (i) a C.sub.1-6 alkyl group which may be substituted with one to four substituents selected from the group consisting of a hydroxyl group, an amino group, a mono- or di-C.sub.1-6 alkylamino group, a C.sub.1-6 alkoxy group, a C.sub.1-6 alkyl-carbonyloxy group and a halogen atom, (ii) an amino group which may be substituted with one to two substituents selected from a C.sub.1-6 alkyl group and a C.sub.1-6 acyl group, or a pyrrolidino, a morpholino, a piperidino or a 1-piperazinyl group, (iii) a hydroxyl group, (iv) a carboxyl group, (v) a nitro group, (vi) a C.sub.1-6 alkoxy group and (vii) a halogen atom;
• m denotes an integer of 0 to 4;
• and n denotes an integer of 0 to 4, or a pharmaceutically acceptable salt thereof.