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US 5,492,906 AGranted
Derivatives of thieno-triazolo-diazepine and therapeutic compositions containing them
AssigneeSociete de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
InventorsPierre Braquet, Andre Esanu, Jean-Pierre Laurent, Alain Rolland
Life of this patent
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Abstract
The invention relates to thieno-triazolo-diazepine derivatives of the formula: ##STR1## wherein Y stands for oxygen or sulphur and R stands for various substituents, to a preparation process of said compounds and to therapeutic compositions containing the same. The compounds are particularly interesting as anti-asthmatic, anti-allergic and gastro-intestinal protectors.
Claims6
A thieno-triazolo-diazepine compound of the formula:
- ##STR14## wherein, Y stands for sulfur and R stands for a lower straight alkenyl group up to C.sub.5,
- a straight or branched alkyl group up to C.sub.20, or cyclic up to C.sub.6,
- an aryl or furyl substituted straight or branched alkyl group up to C.sub.5,
- a phenyl group substituted by one or several alkyl groups, or lower alkoxy groups up to C.sub.5, a phenoxy group, a lower alkyl sulfonyl group up to C.sub.5, or fluorine or chlorine atoms, or trifluoromethyl groups,
- a quinolyl, or
- a sulfonyl group substituted by phenyl or by furyl, thienyl, pyrrolyl, pyridinyl, morpholinyl, or quinolyl;
- or therapeutically acceptable salts thereof;
- or Y stands for oxygen and R stands for-4)
- a lower straight alkenyl group up to C.sub.5,
- a straight or branched alkyl group up to C.sub.20,
- a furyl substituted straight or branched alkyl group up to C.sub.5,
- a phenyl group substituted by one or several alkyl groups, or lower alkoxy groups up to C.sub.5, a phenoxy group, a lower alkyl sulfonyl group up to C.sub.5, or fluorine or chlorine atoms, or trifluoromethyl groups,
- a quinolyl, or
- a sulfonyl group substituted by phenyl or by furyl, thienyl, pyrrolyl, pyridinyl, morpholinyl, or quinolyl;
- or
- therapeutically acceptable salts thereof.
13 more elements
Thieno-triazolo-diazepine derivatives of the formula:
- ##STR15## wherein Y stands for oxygen or sulfur and R stands for a lower straight alkenyl group up to C.sub.5,
- a straight or branched alkyl group up to C.sub.20,
- a furyl substituted straight or branched alkyl group up to C.sub.5,
- a phenyl group substituted by one or several alkyl groups, or lower alkoxy groups up to C.sub.5, a phenoxy group, a lower alkyl sulfonyl group up to C.sub.5, or fluorine or chlorine atoms, or trifluoromethyl groups or,
- a quinolyl or,
- a sulfonyl group substituted by phenyl or by furyl, thienyl, pyrrolyl, pyridinyl, morpholinyl or by quinolyl or therapeutically acceptable salts thereof.
3 more elements
Dependencies are inferred from the claim text.