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US 5,492,898 AGranted
Method of treating endotoxin effects with 2-methylthio-ATP and analogs
AssigneeWisconsin Alumni Research Foundation
InventorsPaul J. Bertics, Richard A. Proctor
Life of this patent
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Abstract
A method of treating mammals to reduce the deleterious effects of endotoxin and endotoxic shock mediators comprising administering a therapeutic amount of a 2-alkylthio-adenosine-5'-nucleotide. The preferred compound is 2-methylthio-adenosine-5'-triphosphate. The nucleotide used in this treatment inhibits lipopolysaccharide-induced GTPase activity.
Claims3
A method of reducing the damage by endotoxin in a mammal comprising administering to said mammal a therapeutic amount of a compound of the following formula:
- ##STR3## wherein, X.sub.1 is --O--, --NH, or --CH.sub.2 --;
- X.sub.2 is oxygen or sulfur;
- X.sub.3 is hydroxyl;
- R.sub.1 is an electron withdrawing sulfur containing alkylthio selected from the group consisting of methylthio, ethylthio, isopropyithio, and isobutyl-thio;
- R.sub.2 is --NH.sub.2, --HN (CH.sub.3) , or --NH (lower alkyl).sub.2 ;
- and
- n is 0or 1.
4 more elements
Dependencies are inferred from the claim text.