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US 5,492,896 AGranted
Pseudopeptides having an antiviral action
AssigneeBayer Aktiengesellschaft
InventorsDieter Habich, Michael Matzke, Klaus Frobel, Thomas Henkel, Hartwig Muller, Karl-Heinz Weber, Jurgen Reefschlager, Gert Streissle, Jutta Hansen, Rainer Neumann, Arnold Paessens
Life of this patent
Estimating the term…
Abstract
The invention relates to new pseudopeptides having an antiviral action, oft he general formula (I) ##STR1## with the meanings given in the description for the substituents, to a process for their preparation and to their use as antiviral agents, in particular against cytomegaloviruses.
Claims9
A pseudopeptide of formula ##STR84## in which R.sup.1 represents an amino-protective group or represents a radical of the formula R.sup.4 --NH--CO--,
- wherein
- R.sup.4 denotes cycloalkyl having 3 to 6 carbon atoms, or denotes straight-chain or branched alkyl having up to 18 carbon atoms, which is optionally substituted by hydroxyl, straight-chain or branched alkoxy having up to 4 carbon atoms, halogen, trifluoromethyl, trifluoromethoxy, cycloalkyl having 3 to 6 carbon atoms or by aryl having 6 to 10 carbon atoms, which can in turn be substituted up to twice in an identical or different manner by carboxyl, cyano, hydroxyl, halogen, perhalogenoalkyl having up to 5 carbon atoms or by straight-chain or branched acyl, alkoxy or alkoxycarbonyl having in each case up to 6 carbon atoms, or
- alkyl is optionally substituted by a group of the formula --CO.sub.2 R.sup.5,
- wherein
- R.sup.5 denotes hydrogen or straight-chain or branched alkyl or alkenyl having in each case up to 8 carbon atoms, which are optionally substituted by phenyl,
- or
- R.sup.4 denotes aryl having 6 to 10 carbon atoms, which is optionally substituted up to 3 times in an identical or different manner by carboxyl, halogen, hydroxyl, cyano, perhalogenoalkyl having up to 5 carbon atoms or by straight-chain or branched acyl, alkoxy, alkoxycarbonyl or vinylalkoxycarbonyl having in each case up to 6 carbon atoms, or
- denotes an amino acid radical of the formula ##STR85## wherein R.sup.6 and R.sup.7 are identical or different and denote hydrogen or methyl, or
- R.sup.6 and R.sup.7 together form a 5- or 6-membered saturated carbocyclic ring,
- or
- R.sup.6 denotes hydrogen or methyl
- and
- R.sup.7 denotes cycloalkyl having 3 to 8 carbon atoms or aryl having 6 to 10 carbon atoms or hydrogen, or denotes straight-chain or branched alkyl having up to 8 carbon atoms, the alkyl optionally being substituted by methylthio, hydroxyl, mercapto, guanidyl or by a group of the formula --NR.sup.9 R.sup.10 or R.sup.11 --OC--,
- wherein
- R.sup.9 and R.sup.10 independently of one another represent hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms or phenyl,
- and
- R.sup.11 denotes hydroxyl, benzyloxy, alkoxy having up to 6 carbon atoms or the abovementioned group --NR.sup.9 R.sup.10,
- or the alkyl is optionally substituted by cycloalkyl having 3 to 8 carbon atoms or by aryl having 6 to 10 carbon atoms, which is in turn substituted by hydroxyl, halogen, nitro, alkoxy having up to 8 carbon atoms or by the group --NR.sup.9 R.sup.10,
- wherein
- R.sup.9 and R.sup.10 have the abovementioned meaning,
- or the alkyl is optionally substituted by a 5- to 6-membered nitrogen-containing heterocycle or indolyl, wherein the corresponding --NH-- functions are optionally protected by alkyl having up to 6 carbon atoms or by an amino-protective group,
- R.sup.8 denotes straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by hydroxyl or straight-chain or branched alkoxy having up to 6 carbon atoms, or
- denotes carboxyl, allyloxycarbonyl, straight-chain or branched alkoxycarbonyl having up to 8 carbon atoms or benzyloxycarbonyl,
- R.sup.2 represents a radical of the formula --SO.sub.2 --R.sup.12,
- wherein
- R.sup.12 denotes methyl or phenyl, which is optionally substituted up to 4 times in an identical or different manner by methyl or methoxy, or denotes a radical of the formula ##STR86## R.sup.3 represents formyl or carboxyl or represents straight-chain or branched alkoxycarbonyl having up to 8 carbon atoms or represents a radical of the formula --CH.sub.2 --OR.sup.13 or --CH(OR.sup.14).sub.2,
- wherein
- R.sup.13 and R.sup.14 are identical or different and denote hydrogen, straight-chain or branched alkyl having up to 6 carbon atoms or a hydroxyl-protective group,
- if appropriate in an isomeric form, or a salt thereof.
26 more elements
Dependencies are inferred from the claim text.