Inhibitors of thrombosis

A compound of the formula:

• ##STR97## wherein (a) R.sub.1 is selected from the group consisting of
• (1) alkyl of about 5 to about 10 carbon atoms if X is --C(.dbd.O)-- or --O--C(.dbd.O)-- or alkyl of 1 to about 10 carbon atoms if X is --S(O.sub.2)--, --NH--S(O.sub.2)-- or --O--S(O.sub.2)--,
• (2) alkyl of 1 to about 3 carbon atoms substituted with cyclic alkyl of about 5 to about 8 carbon atoms,
• (3) alkenyl of about 3 to about 6 carbon atoms optionally substituted with cyclic alkyl of about 5 to about 8 carbon atoms,
• (4) aryl of about 6 to about 14 carbon atoms which is optionally mono-substituted with Y.sub.1 or optionally di-substituted with Y.sub.1 and Y.sub.2,
• (5) aralkyl of about 6 to about 15 carbon atoms which is optionally mono-substituted in the aryl ring with Y.sub.1 or optionally di-substituted in the aryl ring with Y.sub.1 and Y.sub.2,
• (6) aralkenyl of about 8 to about 15 carbon atoms which is optionally mono-substituted in the aryl ring with Y.sub.1 or optionally di-substituted in the aryl ring with Y.sub.1 and Y.sub.2,
• (7) perfluoroalkyl of 1 to about 12 carbon atoms,
• (8) perfluoroaryl of about 6 to about 14 carbon atoms,
• (9) trimethylsilylalkyl of 4 to about 8 carbon atoms, ##STR98## wherein Y.sub.1 and Y.sub.2 are independently selected from the group consisting of bromo, chloro, fluoro, Z.sub.1 --, HO--, Z.sub.1 --O--, NH.sub.2 --, Z.sub.1 --NH--, (Z.sub.1, Z.sub.2)N--, Z.sub.1 --C(O)--NH--, HS--, Z.sub.1 --S--, Z.sub.1 --S(O)--, Z.sub.1 --S(O.sub.2)--, HO--S(O.sub.2)--, Z.sub.1 --O--S(O.sub.2)--, NH.sub.2 --S(O.sub.2)-- and Z.sub.1 --NH--S(O.sub.2)--, wherein Z.sub.1 and Z.sub.2 are independently selected from the group consisting of trifluoromethyl, pentafluoroethyl, alkyl of 1 to about 12 carbon atoms, aryl of about 6 to about 14 carbon atoms, and aralkyl of about 6 to about 15 carbon atoms;
• (b) X is --C(.dbd.O)--, --O--C(.dbd.O)--, --S(O.sub.2)--, --NH--S(O.sub.2)--, --O--S(O.sub.2)--;
• (c) m is 1 or 2;
• (d) R.sub.2 is --CO.sub.2 H, --CO.sub.2 R', or ##STR99## wherein R' is alkyl of 1 to about 4 carbon atoms, aryl of about 6 to about 14 carbon atoms, aralkyl of about 6 to about 14 carbon atoms;
• and
• (e) R.sub.3 is --(CH.sub.2).sub.3 --NH--C(.dbd.NH)--NH.sub.2 ;
• or a pharmaceutically acceptable salt thereof.