Compositions for treating wrinkles comprising a peptide
AssigneeThe Procter & Gamble Company
InventorsCharles C. Bascom, Andrew W. Fulmer
Life of this patent
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Abstract
The present invention relates to topical compositions comprising a peptide having the formula Q.sup.a -(Xaa).sub.n -Q.sup.c wherein Q.sup.a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl; Q.sup.c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, alkylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (alkyl)(arylalkyl)amino, (aryl)(arylalkyl)amino, and amino; n is an integer selected from the group consisting of 3, 4, 5 and 6; Xaa is independently any amino acid; and at least three of the amino acids are selected from the group consisting of arginine and lysine.
Claims30
A topical composition comprising:
- a) peptide useful for cosmetic treatment of mammalian skin wrinkles having the amino acid sequence
- Q.sup.a -(Xaa).sub.n -Q.sup.c
- wherein Q.sup.a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl;
- Q.sup.c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, alkylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (allcyl)(arylalkyl)amino, (aryl)(arylaikyl)amino, and amino;
- n is from 3 to 6;
- Xaa is independently any amino acid;
- wherein at least three of the Xaa are independently selected from the group consisting of arginine and lysine;
- and
- b) a pharmaceutically-acceptable carrier or cosmetically-acceptable carrier, wherein the carrier is a topical carrier comprising an emollient.
A method for the cosmetic treatment of mammalian skin wrinkles comprising topically applying to mammalian skin in need of such treatment a composition comprising:
- a) peptide useful for the cosmetic treatment of mammalian skin wrinkles having the areinc acid sequence
- Q.sup.a -(Xaa).sub.n -Q.sup.c
- wherein Q.sup.a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl;
- Q.sup.c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, allcylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (alkyl)(arylalkyl)amino, (aryl)(arylalkyl)amino, and amino;
- n is from 3 to 6;
- Xaa is independently any areinc acid;
- wherein at least three of the Xaa are independently selected from the group consisting of arginine and lysine;
- and
- b) a pharmaceutically-acceptable carrier or cosmetically-acceptable carrier wherein the carrier is a topical carrier comprising an emollient.
A peptide useful for the cosmetic treatment of mammalian skin wrinkJes having the amino acid sequence Q.sup.a -Arg-Lys-Arg-Q.sup.c, wherein Q.sup.a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl;
- and Q.sup.c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, alkylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (alkyl)(arylalkyl)amino, (aryl)(arylalkyl)amino, and amino.
A peptide useful for the cossmetic treatment of mammalian skin wrinkles having the amino acid sequence Q.sup.a -Arg-Gly-Arg-Lys-Q.sup.c, wherein Q.sup.a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl;
- and Q.sup.c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, alkylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (alkyl)(arylalkyl)amino, (aryl)(arylalkyl)amino, and amino.
A peptide useful for the cosmetic treatment of mammalian skin wrinkles having the amino acid sequence Q.sup.a -Lys-Arg-Ser-Arg-Q.sup.c, wherein Q.sub.a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl;
- and Q.sup.c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, allcylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (alkyl)(arylalkyl)amino, (aryl)(arylalkyl)amino, and amino.
A topical composition comprising:
- a) a safe and effective amount of a peptide useful for the cosmetic treatment of mammalian skin wrinkles having the amino acid sequence
- Q.sup.a -(Xaa)n Arg Ser Arg Lys (Xaa)n-Q.sup.c
- wherein each n is independently an integer selected from the group consisting of 0, 1, 2 and 3, each Xaa is independently any amino acid, each amino acid is
- protected or unprotected, Q.sup.a is selected from the group consisting of hydrogen and an amino-terminus blocking group, and Q.sup.c is selected from the group consisting of hydrogen and a carboxy-terminus blocking group;
- and
- b) a safe and effective mount of a topical carrier comprising an emollient.
Dependencies are inferred from the claim text.