Means for detecting familial colon cancer (FCC)

A method for detecting the presence in an individual of the gene for familial colon cancer (FCC) comprising:

• obtaining a DNA sample of the individual;
• determining the presence or absence of a restriction fragment length polymorphism (RFLP) on human chromosome band 2p13-21 in the DNA sample, wherein said DNA polymorphism is genetically linked to FCC, wherein the presence of said DNA polymorphism is correlated with the presence of the FCC gene, and wherein said step of determining the presence or absence of a DNA polymorphism is carried out by:
• (a) digesting DNA from said individual with a restriction endonuclease;
• (b) separating fragments obtained from said digestion;
• (c) detecting said RFLP with a hybridization probe capable of hybridizing to and identifying said RFLP, thereby generating a restriction pattern;
• and
• (d) correlating the presence or absence of said RFLP in said digest with the respective presence or absence of the FCC gene.

A method for detecting the presence in an individual of the gene for familial colon cancer (FCC) comprising:

• obtaining a DNA sample of the individual;
• determining the presence or absence of a DNA polymorphism on human chromosome band 2p13-21 in the DNA sample, wherein said DNA polymorphism is genetically linked to FCC, wherein the presence of said DNA polymorphism is correlated with the presence of the FCC gene, and wherein said step of determining the presence or absence of a DNA polymorphism is carried out by:
• (a) amplifying a region of DNA from said individual to form DNA fragments, said region of DNA containing a polymorphism;
• (b) separating said DNA fragments obtained from said amplification;
• (c) detecting said polymorphism among said DNA fragments;
• and
• (d) correlating the presence or absence of said polymorphism among said DNA fragments with the respective presence or absence of the FCC gene.