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US 5,491,241 AGranted
Bicyclic intermediates for excitatory amino acid receptor antagonists
AssigneeEli Lilly and Company
InventorJames A. Monn
Life of this patent
Estimating the term…
Abstract
This invention provides novel bicyclic compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides intermediates useful in the synthesis of excitatory amino acid antagonists.
Claims6
A compound of the formula ##STR15## wherein:
- R.sup.4 is C.sub.1 -C.sub.6 alkyl;
- C.sub.1 -C.sub.6 alkyl substituted by one or more of hydroxy, fluoro, chloro, bromo and iodo;
- C.sub.3 -C.sub.7 cyclic alkyl;
- or phenyl (C.sub.1 -C.sub.4)alkyl in which the phenyl group is unsubstituted or is substituted with one or two moieties chosen from the group consisting of halogen, hydroxy, cyano, nitro, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 alkoxy, (C.sub.1 -C.sub.6 alkoxy)carbonyl, carboxymethyl, hydroxymethyl, amino, aminomethyl and trifluoromethyl;
- and
- R.sup.6 is formyl;
- (C.sub.1 -C.sub.6 alkyl)carbonyl;
- (C.sub.1 -C.sub.6 alkoxy) carbonyl;
- phenyloxycarbonyl in which the phenyl group is unsubstituted or substituted with one or two moieties chosen from the group consisting of halogen, hydroxy, cyano, nitro, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 alkoxy, (C.sub.1 -C.sub.6 alkoxy)carbonyl, carboxymethyl, hydroxymethyl, amino, aminomethyl and trifluoromethyl;
- or phenyl(C.sub.1 -C.sub.6 alkoxy)carbonyl in which the phenyl group is unsubstituted or substituted with one or two moieties chosen from the group consisting of halogen, hydroxy, cyano, nitro, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 alkoxy, (C.sub.1 -C.sub.6 alkoxy)carbonyl, carboxymethyl, hydroxymethyl, amino, aminomethyl and trifluoromethyl.
7 more elements
A compound of the formula ##STR16## wherein:
- R.sup.4 is C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkyl substituted by one or more of hydroxy, fluoro, chloro, bromo and iodo;
- C.sub.3 -C.sub.7 cyclic alkyl;
- or phenyl(C.sub.1 -C.sub.4)alkyl in which the phenyl group is unsubstituted or is substituted with one or two moieties chosen from the group consisting of halogen, hydroxy, cyano, nitro, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 alkoxy, (C.sub.1 -C.sub.6 alkoxy)carbonyl, carboxymethyl, hydroxymethyl, amino, aminomethyl and trifluoromethyl;
- and
- R.sup.6 is formyl;
- (C.sub.1 -C.sub.6 alkyl)carbonyl;
- (C.sub.1 -C.sub.6 alkoxy)carbonyl, phenyloxycarbonyl in which the phenyl group is unsubstituted or substituted with one or two moieties chosen from the group consisting of halogen, hydroxy, cyano, nitro, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 alkoxy, (C.sub.1 -C.sub.6 alkoxy)carbonyl, carboxymethyl, hydroxymethyl, amino, aminomethyl and trifluoromethyl;
- or phenyl(C.sub.1 -C.sub.6 alkoxy)carbonyl in which the phenyl group is unsubstituted or substituted with one or two moieties chosen from the group consisting of halogen, hydroxy, cyano, nitro, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 alkoxy, (C.sub.1 -C.sub.6 alkoxy)carbonyl, carboxymethyl, hydroxymethyl, amino, aminomethyl and trifluoromethyl.
5 more elements
Dependencies are inferred from the claim text.