Back to results
US 5,491,227 AGranted
Controlled molecular weight reduction of polymers
AssigneeGenzyme Corporation
InventorsRobert D. Casson, John A. Lovelady
Life of this patent
Estimating the term…
Abstract
A method for the controlled molecular weight reduction of a polymer which comprises subjecting the polymer to pressure homogenization is disclosed. The preferred polymers are polysaccharides, particularly hyaluronic acid.
Claims1
A method for the controlled number average molecular weight reduction of an aqueous solution of hyaluronic acid comprising:
- subjecting the hyaluronic acid to pressure homogenization in a single passage at a pressure of from about 10 to about 25 MPa, and
- obtaining a hyaluronic acid solution wherein said hyaluronic acid has a number average molecular weight of from about 1.2 to about 1.5.times.10.sup.6 D.
Dependencies are inferred from the claim text.