Ferritin with ferrimagnetically ordered ferrite core and method technical field
AssigneeProtein Magnetics
InventorStephen Mann
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Abstract
Biocompatability and orders greater magnetic responsiveness characterize a uniquely useful new product, magnetoferritin, comprising ferritin having a ferrimagnetically ordered ferrite core in place of the naturally occurring ferrihydrite core. A method of preparation is disclosed.
Claims11
Ferritin product having a ferrimagnetically ordered core, in which said core comprises magnetite or maghemite, has a face-centered cubic spinel crystal structure in the size of up to 10 nm, has a magnetic dipole moment per particle above 10.sup.-17 ergs/gauss, has a blackish or red/brown appearance in dilute aqueous solution and is perceptibly attracted to a samarium-cobalt permanent magnet.
Method of preparing a ferritin product having a ferrimagnetically ordered ferrite core, in which said core comprises magnetite or maghemite, has a face-centered cubic spinel crystal structure in the size of up to 10 nm, and has a magnetic dipole moment per particle above 10.sup.-17 ergs/gauss, including removing naturally occurring ferrihydrite iron core from the ferritin cavity to form apoferritin in aqueous solution, incorporating the ferrimagnetically ordered ferrite by oxidation-precipitating the said ferrite from an aqueous Fe(II) solution into said cavity.
Dependencies are inferred from the claim text.