3-amidoindolyl derivative

A compound of the formula:

• ##STR87## in which Z is represented by H, C.sub.1 -C.sub.4 alkyl, phenyl, substituted phenyl in which the phenyl ring may be optionally substituted with up to 3 substituents, wherein each substituent is independently selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, CF.sub.3, OCF.sub.3, OH, CN, NH.sub.2 and NO.sub.2, or a phenylalkyl substituent in which the phenyl ring may be optionally substituted with up to 3 substituents, wherein each substituent is independently selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, CF.sub.3, OCF.sub.3, OH, CN, NH.sub.2 and NO.sub.2 :
• R is represented by hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, CF.sub.3, OCF.sub.3, OH, NO.sub.2 or CN;
• B is represented by hydrogen, C.sub.1 -C.sub.4 alkyl, phenylalkyl substituent in which the phenyl ring may be optionally substituted with up to 3 substituents, wherein each substituent is independently selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, CF.sub.3, OCF.sub.3, OH, CN, NH.sub.2 and NO.sub.2, or --CH.sub.2 --COR.sub.2 ;
• X is represented by CO or SO.sub.2 ;
• A is represented by a substituent selected from the group consisting of:
• ##STR88## R.sub.1 and R.sub.2 are each independently represented by a substituent selected from the group consisting of --OH, --OR.sub.3, --NR.sub.4 R.sub.5, --OCH.sub.2 OR.sub.3, and --O--(CH.sub.2).sub.m --NR.sub.6 R.sub.7, in which m is an integer from 1-4;
• R.sub.3 is represented by C.sub.1 -C.sub.4 alkyl, phenyl, substituted phenyl in which the phenyl ring may be optionally substituted with up to 3 substituents, wherein each substituent is independently selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, CF.sub.3, OCF.sub.3, OH, CN, NH.sub.2 and NO.sub.2 or an phenylalkyl substituent in which the phenyl ring may be optionally substituted with up to 3 substituents, wherein each substituent is independently selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, CF.sub.3, OCF.sub.3, OH, CN, NH.sub.2 and NO.sub.2 ;
• R.sub.4 and R.sub.5 are each independently represented by hydrogen or a C.sub.1 -C.sub.4 alkyl;
• R.sub.6 and R.sub.7 are each independently represented by hydrogen or a C.sub.1 -C.sub.4 alkyl;
• and the pharmaceutically acceptable salts thereof, with the proviso that with respect to a substituted phenyl ring, there may not be more than one NH.sub.2 or NO.sub.2 nor both an alkoxy and a hydroxy on any one phenyl ring.