Antitumor treatment method
AssigneeKabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
InventorsYoshinori Nakagawa, Tetsuo Kimoto, Makoto Takeuchi
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Abstract
This invention relates to an antitumor agent containing as the effective ingredient a cyanine dye, shown by the general formula: ##STR1## where X.sup.- is a physiologically-acceptable anion; Z.sup.+, a group of the formula ##STR2## R, an alkyl group having a carbon chain length of 1-5; and R', either hydrogen atom or an alkoxy group. Oral and parenteral administration of the antitumor agent remarkably activates macrophages in vivo and enhances their functions to allow them to inhibit the growth and metastasis of tumors, as well as to accelerate their natural death through cicatrization.
Claims6
A method for activating macrophages in a mammal comprising:
- administering to said mammal, an amount sufficient for said activation of a cyanine dye of the formula:
- ##STR12## wherein X.sup.- is a physiologically-acceptable anion selected from the group consisting of chloride, bromide, iodide, sulfuric ion, nitric ion, perchloric ion, p-toluenesulfonic ion, acetic ion, nicotinic ion and orotic ion;
- Z.sup.+ is a group of the formula:
- ##STR13## R is an alkyl group having a carbon chain length of 1-5;
- and R' is either hydrogen atom or an alkoxy group,
- said administration being carried out at a dose of about 0.1-50 .mu.g/kg/day for said mammal.
Dependencies are inferred from the claim text.