Imidazopyridazines, their production and use
AssigneeTakeda Chemical Industries, Ltd.
InventorsAkio Miyake, Yasuhiko Kawano, Yasuko Ashida
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AssigneeTakeda Chemical Industries, Ltd.
InventorsAkio Miyake, Yasuhiko Kawano, Yasuko Ashida
Estimating the term…
Novel compound of the general formula: ##STR1## wherein R.sup.1 stands for a hydrogen atom, an optionally substituted lower alkyl group or a halogen atom; R.sup.2 and R.sup.3 respectively stand for a hydrogen atom or an optionally substituted lower alkyl group, provided that either R.sup.2 or R.sup.3 is a hydrogen atom, the other being an optionally substituted lower alkyl group, or R.sup.2 and R.sup.3 may, taken together with the adjacent --C=C-- group, form a 5- to 7-membered ring; X stands for an oxygen atom or S(O).sub.p (p stands for an integer from 0 to 2; Y stands for a group of the formula: ##STR2## (R.sup.4 and R.sup.5 respectively stand for a hydrogen atom or an optionally substituted lower alkyl group) or a divalent group derived from an optionally substituted 3- to 7-membered homocyclic or heterocyclic ring; R.sup.6 and R.sup.7 each stands for a hydrogen atom, an optionally substituted lower lakyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group, or R.sup.6 and R.sup.7 may, taken together with the adjacent nitrogen atom, form an optionally substituted nitrogen-containing heterocyclic group; m stands for an integer from 0 to 4; and n stands for an integer from 0 to 4, or a salt thereof, which has excellent anti-PAF activities, and is of value as an antiasthmatic agent, and their production, intermediates and pharmaceutical compositions.
A compound of the formula:
6-(2,2-dimethyl-3-sulfamoyl-1-propoxy) -7-methylimidazo [1,2-b]pyridazine.
6-(2,2 -dimethyl -3- sulfamoyl -1-propoxy)-8 -methylimidazo [1,2,-b]pyridazine.
6-(2,2 -diethyl -3- sulfamoyl -1-propoxy)-7 -methylimidazo [1,2-b]pyridazine.
Dependencies are inferred from the claim text.