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US 5,491,132 AGranted
Amino acid derivatives, a process for the preparation thereof and pharmaceutical composition comprising the same
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsKeiji Hemmi, Masahiro Neya, Hiroshi Marusawa, Shinya Watanabe, Masashi Hashimoto
Life of this patent
Estimating the term…
Abstract
This invention relates to new amino acid derivatives and pharmaceutically acceptable salts thereof, wherein the amino acid derivatives are useful in the treatment and/or prevention of hypertension, heart failure, renal diseases or glaucoma.
Claims11
A compound having the formula:
- ##STR13## wherein R.sup.1 is morpholinocarbonyl or thiomorpholinocarbonyl;
- R.sup.2 is methyl;
- R.sup.3 is isobutyl or 2-ethylbutyl;
- R.sup.4 is methyl;
- X is ethylene;
- Y.sup.1 is a single bond or ##STR14## wherein R.sup.5 is methyl;
- and Y.sup.2 is --NH--;
- or
- its pharmaceutically acceptable salt.
6 more elements
A compound having the formula:
- ##STR15## wherein R.sup.1 is selected from the group consisting of morpholinocarbonyl, thiomorpholinocarbonyl, piperidinocarbonyl, hexahydro-1H-azepin-1-ylcarbonyl, dipropylcarbamoyl, 1,2,3,4-tetrahydro-2-isoquinolylcarbonyl and pyridyl;
- R.sup.2 is lower alkyl
- R.sup.3 is selected from the group consisting of lower alkyl and cyclo(lower) alkyl substituted lower alkyl;
- R.sup.4 is lower alkyl;
- X is lower alkylene;
- Y.sup.1 is a single bond or ##STR16## wherein R.sup.5 is lower alkyl;
- and Y.sup.2 is --NH--;
- or
- its pharmaceutically acceptable salt.
6 more elements
A compound having the formula:
- ##STR17## wherein R.sup.1 is selected from the group consisting of morpholinocarbonyl, thiomorpholinocarbonyl, piperidinocarbonyl, hexahydro-1H-azepin-1-ylcarbonyl, di(lower) alkylcarbamoyl, 1,2,3,4-tetrahydro-2-isoquinolylcarbonyl, lower alkanoyl and pyridyl;
- R.sup.2 is lower alkyl
- R.sup.3 is selected from the group consisting of lower alkyl and cyclo (lower) alkyl substituted lower alkyl;
- R.sup.4 is lower alkyl;
- X is lower alkylene;
- Y.sup.1 is a single bond or ##STR18## wherein R.sup.5 is lower alkyl;
- and Y.sup.2 is --NH--;
- or
- its pharmaceutically acceptable salt.
6 more elements
Dependencies are inferred from the claim text.