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US 5,491,128 AGranted
Aglycons of A/16686 antibiotics
AssigneeGruppo Lepetit S.p.A.
InventorsRomeo Ciabatti, Bruno Cavalleri
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Abstract
The invention concerns the aglycons of factors A1, A2, A3, A'1, A'2, A'3 of antibiotic A/16686, their corresponding tetrahydroderivatives and mixtures thereof. The aglycons are produced by the selective hydrolysis of antibiotic A/16686 factor A1, A2, A3, A'1, A'2 or A'3. The compounds have antibacterial activity against widely diffused gram positive bacteria and are particularly useful for topical treatment of wound infections and acne.
Claims6
A compound of the formula:
- ##STR2## in which R is represented by a substituent selected from the group consisting of
- -CO-CH.dbd.CH-CH.dbd.CH-CH.sub.2 -CH.sub.2 -CH.sub.3,
- -CO-CH.dbd.CH-CH.dbd.CH-CH.sub.2 -CH(CH.sub.3).sub.2,
- -CO-CH.dbd.CH-CH.dbd.CH-CH-CH.sub.2 -CH.sub.2 -CH(CH.sub.3).sub.2,
- -CO(CH.sub.2).sub.6 -CH.sub.3,-CO(CH.sub.2).sub.5 CH(CH.sub.3).sub.2 and
- -CO(CH.sub.2).sub.6 CH(CH.sub.3).sub.2, a pharmaceutically acceptable acid addition salt thereof, or a mixture of said compounds present in any proportion.
3 more elements
Dependencies are inferred from the claim text.