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US 5,491,077 AGranted
Microbial method
AssigneeMerck & Co., Inc.
InventorsMichel M. Chartrain, Shieh-Shung T. Chen, George M. Garrity, Brian Heimbuch, Christopher Roberge, Ali Shafiee
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Abstract
The present invention provides a process for the stereoselective reduction of phenylalkyl ketones to their corresponding (S)-hydroxy compounds. The process utilizes the novel microorganism Microbacterium MB 5614 to effectuate the chiral reduction. The present invention also provides said novel Microbacterium, which has been deposited with the ATCC and assigned the accession number ATCC 55557.
Claims8
A process for the preparation of a compound of formula (III) ##STR5## which comprises:
- (1) contacting a compound of formula (IV) ##STR6## with Microbacterium MB5614 ATCC 55557, or a mutant thereof;
- and (2) isolating the compound of formula (III);
- wherein
- A is --CH.dbd.CH--S-- or --CH.dbd.CH--CH.dbd.CH--CH--;
- R.sup.1 and R.sup.2 are independently hydrogen or a halogen;
- R.sup.3 is CO.sub.2 R.sup.6, COR.sup.6 or C(R.sup.7).sub.2 --O--R.sup.8 ;
- R.sup.6 is hydrogen or lower alkyl;
- R.sup.7 is lower alkyl;
- and
- R.sup.8 is hydrogen or a hydroxy protecting group.
7 more elements
Dependencies are inferred from the claim text.