Directed delivery of radioprotectants using a receptor specific carrier
AssigneeAdvanced Magnetics, Inc.
InventorsPhilip Enriquez, Chu W. Jung, Ernest V. Groman
Life of this patent
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Abstract
Chemoactive radioprotectants are coupled to carrier molecules capable of binding cell receptors to form complexes that can be directed to specific non-target cells in a mixture of cells prior to radiation of the mixture so that target cells are selectively destroyed while the non-target cells are protected from radiation. Radioprotection of non-target cells is provided by using chemoactive radioprotectant complexes.
Claims12
A method of treating a mixture of cells containing target cells to be destroyed by radiation therapy and non-target cells so as to protect specific non-target cells in the mixture against damage, comprising:
- (i) selecting a radioprotectant compound;
- (ii) forming a complex of the radioprotectant compound and a carrier wherein the carrier is both (i) a polysaccharide, and (ii) capable of being bound to a receptor mediated endocytosis (RME) receptor, the RME receptor being present on the non-target cells and substantially absent on the target cells;
- and
- (iii) administering the complex to the mixture of cells.
A method of treating animal subjects having diffuse cancerous infiltrations with radiation comprising:
- (i) selecting a polysaccharide carrier capable of interacting with an RME cell receptor;
- (ii) modifying the carrier to form a complex with a radioprotectant agent;
- (iii) administering to the subject an effective dose of the complex prior to radiation treatment so as to protect non-target cells during subsequent radiation of tissues at doses sufficient to destroy malignant cells.
Dependencies are inferred from the claim text.