Encapsulated perfluorocarbons
AssigneeTemple University of the Commonwealth System of Higher Education
InventorTully J. Speaker
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Abstract
An artificial blood substitute comprising Lewis acid--Lewis base salt film microcapsule having a perfluorocarbons encapsulated therein. The Lewis base may be a polyoxyalkylene adduct of an amine, having the structure: ##STR1## in which, independently, ##STR2## said Lewis acid may be a polyoxyalkylene derivative of a polymeric acid having the structure ##STR3## in which c- and d- type repeat units are randomly distributed within the polymer, c=70 to 3150, c-type repeat units comprise from 50-90% of the total polymer.
Claims15
A Lewis acid-Lewis base salt film microcapsule having a microcapsule wall and perfluorocarbon as a core material, wherein said Lewis acid is selected from the group consisting of arabic acid, acacia gum carboxymethylcellulose, ghatti gum, guar gum and a polyoxyalkylene derivative of a polymeric acid having the structure ##STR8## in which c- and d- type repeat units are randomly distributed within the polymer, c=70 to 3150, c-type repeat units consist essentially of from 50-90% of the total polymer, d=70-1750, the sum of c+d is in the range from about 140 to about 3500 and in which:
- ##STR9## where R' and R" independently=H or CH.sub.3 and e=7-75, f=7-75, and the sum of e+f=14 to 85,
- and said Lewis base is a simple amine selected from the group consisting of n-hexylamine, 2,4-dimethylpentylamine, octadecylamine, ethylenediamfne, piperazine, tetraethylenetriamine and polyethyleneimine and a polyoxyalkylene adduct of an amine having the structure ##STR10## in which, independently, ##STR11## wherein when said Lewis base is a polyoxyalkylene adduct of an amine said Lewis acid is not a polyoxyalkylene derivative of a polymeric acid, and when said Lewis acid is a polyoxyalkylene derivative of a polymeric acid said Lewis base is not a polyoxylene adduct of an amine, and
- wherein said Lewis acid is in a concentration of 1-10% weight by volume and said Lewis base is in a stoichiometric amount sufficient to form a neutral salt film.
A method of making a microencapsulated perfluorocarbon having a wall and a core, consisting essentially of combining:
- a. an aqueous phase including a Lewis acid wherein said Lewis acid is selected from the group consisting of arabic acid, acacia gum carboxymethylcellulose, ghatti gum, guar gum, and a polyoxyalkylene derivative of a polymeric acid having the structure ##STR12## in which c- and d- type repeat units are randomly distributed within the polymer, c=70 to 3150, c-type repeat units consist essentially of from 50-90% of the total polymer, d=70 to 1750, the sum of c+d is the range from about 140 to 3500 and in which:
- ##STR13## where R' and R" independently=H or CH.sub.3 and e=7-75, f=7-75, and the sum of e+f=14 to 85,
- with
- b. a non-aqueous phase including
- (1) a stoichiometric equivalent of a Lewis base,
- wherein said Lewis base is selected from the group consisting of n-hexylamine, 2,4-dimethylpentylamine, octadecylamine, ethylenediamine, piperazine, tetraethylenetriamine and polyethyleneimine, and a polyoxyethylene adduct of an amine having the structure ##STR14## in which, independently, ##STR15## and wherein said Lewis acid is in a concentration of 1-10% weight by volume and said Lewis base is in a stoichiometric amount sufficient to form a neutral salt film,
- (2) a perfluorcarbon selected from the group consisting of perfluoroalkanes, perfluorocycloalkanes, perfluoroalkenes, perfluoroamines, perfluoroethers, and halogen substituted perfluorocarbons;
- c. dispersing said aqueous and said nonaqueous phases together to form an emulsion, wherein said perfluorocarbon is disposed in said core.
Dependencies are inferred from the claim text.