Covalent bonding of active agents to skin, hair or nails
AssigneeChesebrough-Pond's USA Co., Division of Conopco, Inc.
InventorsNorman K. Richardson, Kurt M. Schilling, David J. Pocalyko, Peter L. Bailey
Life of this patent
Estimating the term…
Abstract
Transglutaminase crosslinks proteins by catalyzing the formation of isopeptide bonds between lysine and glutamine residues. Transglutaminase may be used to crosslink beneficial actives containing an amine moiety to glutamine residues in skin, hair or nails. A variety of beneficial actives, e.g., sunscreens, antimicrobial compounds, skin conditioning agents, hair conditioning agents, anti-inflammatory compounds, antioxidants, coloring agents, perfumes, insect repellants, can thus be delivered to human skin, hair, or nails.
Claims9
A composition for topical application to human skin, hair, or nails, the composition comprising:
- a) an effective amount of at least one active ingredient which includes at least one --R'NH.sub.2 group and is selected from the group consisting of proteins and peptides,
- wherein R' is a straight aliphatic hydrocarbon chain containing from 1 to 8 carbon atoms;
- b) transglutaminase in an amount effective to catalyze the crosslinking of the active ingredient to glutamine residues in human skin, hair, or nails;
- and
- c) a pharmaceutically acceptable carrier in an amount effective to deliver transglutaminase and the skin benefit ingredient to human skin, hair, or nails.
A composition for topical application to human skin, hair, or nails, the composition comprising:
- a) an effective amount of at least one active ingredient which is modified to include at least one --R'NH.sub.2 group attached to the active ingredient by hydrolyzable linkage as represented by formula (I) ##STR16## wherein R' is (CH.sub.2).sub.a (CHNH.sub.2).sub.b X is oxygen, nitrogen, or sulphur,
- R is the active ingredient part of a modified active,
- a is an integer from 5 to 12;
- b is a number from 0 to 30, and
- c is a number from 1 to 4.
- b) transglutaminase in an amount effective to catalyze the crosslinking of the active ingredient to glutamine residues in human skin, hair, or nails;
- and
- c) a pharmaceutically acceptable carrier in an amount effective to deliver transglutaminase and the skin benefit ingredient to human skin, hair, or nails.
Dependencies are inferred from the claim text.