Process for preparing cyclic ketones
AssigneeHoechst Celanese Corporation
InventorApurba Bhattacharya
Life of this patent
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Abstract
The present invention provides a novel process for preparing cyclic ketones, such as indanones, which comprises the steps of (a) subjecting a substituted ketone to suitable methylenation conditions in the presence of a methylene transfer agent and an acylating agent for a sufficient period of time and under suitable conditions of temperature and pressure to form the corresponding alpha, beta unsaturated ketone, and (b) subjecting said unsaturated ketone to suitable cyclization conditions in the presence of a suitable acid or base for a sufficient period of time and under suitable conditions of temperature and pressure to form said cyclic ketones.
Claims19
A process for preparing cyclic ketones which comprises the steps of (a) subjecting a substituted ketone to suitable methylenation conditions in the presence of hexamethylenetetramine and an acylating agent for a sufficient period of time and under suitable conditions of temperature and pressure to form the corresponding alpha, beta unsaturated ketone, and (b) subjecting said unsaturated ketone to suitable cyclization conditions in the presence of a suitable acid or base for a sufficient period of time and under suitable conditions of temperature and pressure to form said cyclic ketones.
A process for preparing aryl alkyl indanones which comprises the steps of (a) subjecting an aryl alkyl ketone to suitable methylenation conditions in the presence of hexamethylenetetramine and an acylating agent for a sufficient period of time and under suitable conditions of temperature and pressure to form an acrylophenone;
- and (b) subjecting said acrylophenone to suitable cyclization conditions in the presence of a suitable acid or base for a sufficient period of time and under suitable conditions of temperature and pressure to form said aryl alkyl indanones.
Dependencies are inferred from the claim text.