Polypeptides that potentiate bactericidal/permeability-increasing protein and methods for treating bacterial infections
OwnerPeter Elsbach, Chean Eng Ooi +1inventors
InventorsPeter Elsbach, Chean Eng Ooi, Jerrold Weiss
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Abstract
Disclosed herein are purified isolated mammals polypeptides having the property of potentiating the bacterial growth inhibitory activity of bactericidal/permeability-increasing protein and pharmaceutical formulations comprising these polypeptides. Also disclosed is a method for obtaining mammalian polypeptides having the property of potentiating the bacterial growth inhibitory activity of bactericidal/permeability-increasing protein potentiating activity, and methods for treating gram-negative bacterial infections in mammals and for neutralizing lipopolysaccharides. Also disclosed is a method for the treatment of diseases caused by endotoxins in mammals.
Claims2
An isolated nucleic acid comprising a DNA sequence encoding a polypeptide of mammalian origin having a molecular weight of about 15,000 daltons and bactericidal/permeability-increasing protein potentiating activity.
Dependencies are inferred from the claim text.