Calixarene chloride-channel blockers

A composition comprising a calixarene derivative of the formula:

• ##STR26## wherein R is an acidic group selected from the group consisting of R.sup.1 SO.sub.3 X and R.sup.1 COOX, wherein X is H, Na, K, Rb, Cs, Li, NH.sub.4 .sup.+ or N(R.sub.i).sub.4.sup.+ where R.sub.i is H, a C.sub.1-4 alkyl or an aryl, and R.sup.1 is selected from the group consisting of ##STR27## where m=1-2, and R.sup.3 and R.sup.4 the same or different is each H, a C.sub.1-4 alkyl or a C.sub.1-4 alkoxy, and a nitrogen-containing group of the formula ##STR28## wherein R.sup.5 is a C.sub.1-4 alkyl or a C.sub.1-4 alkoxy, R.sup.6 is a C.sub.1-4 alkyl or a C.sub.1-4 alkoxy, and A is ##STR29## where R.sup.7 and R.sup.8, the same or different, is each H, a C.sub.1-4 alkyl or a C.sub.1-4 alkoxy, and R.sup.9 and R.sup.10, the same or different, is each H, a C.sub.1-4 alkyl or a C.sub.1-4 alkoxy;
• R' is selected from the group consisting of H, a C.sub.1-4 alkyl, a C.sub.1-4 alkoxy, an acid group, an ester group, an aryl, or --CH.sub.2 CONR.sup.5 R.sup.6 where R.sup.5 and R.sup.6 are as previously defined;
• and
• n is an integer of 4-8.