Indolocarbazole derivatives and the use thereof
AssigneeGoedecke Aktiengesellschaft
InventorsJurgen Kleinschroth, Johannes Hartenstein, Christoph Schachtele, Claus Rudolph
Life of this patent
Estimating the term…
Abstract
The present invention provides indolocarbazole derivatives of the formula ##STR1## as well as the regioisomeric mixtures thereof, pharmacologically acceptable salts thereof, processes for the preparation thereof, and pharmaceutical compositions containing them for the treatment and/or prophylaxis of heart and blood vessel diseases, such as thromboses, arterioscleroses, hypertonias, of bronchopulmonary diseases, inflammatory processes, allergies, cancers and degenerative damage of the central nervous system, and for the treatment of viral diseases.
Claims7
A compound of formula ##STR6## or a pharmaceutically acceptable salt thereof or a regioisomeric mixture thereof wherein one of R.sup.1 and R.sup.2 is a hydrogen or a straight or branched alkyl of from 1 to 6 carbon atoms and the other of R.sup.1 and R.sup.2 is a straight or branched carboxyalkyl, azidoalkyll, amidinoalkyl, amidinothioalkyl, (2-nitroguanidino) alkyl, containing in each case from 1 to 6 carbon atoms, or is
- --(CH.sub.2).sub.2 --CO--NR.sup.3 R.sup.4 wherein R.sup.3 and R.sup.4 are each independently hydrogen, alkyl of from 1 to 4 carbon atoms or benzyl;
- and
- X and Y are each hydrogen or one of X and Y is hydrogen and the other is hydrogen or alkoxy of from 1 to 4 carbon atoms.
A compound selected from the group consisting of
- 12-(3-azidopropyl)-6,7,12,13-tetrahydro-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c ]carbazole, and
- 13-(3-azidopropyl)-6,7,12,13-tetrahydro-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c ]carbazole.
A compound of the formula 12-(2-carboxyethyl)-6,7,12,13-tetrahydro-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4 -c]carbazole.
Dependencies are inferred from the claim text.