Anti-fungal triazole derivatives, their uses
AssigneeSankyo Company, Limited
InventorsSadao Oida, Takeo Miyaoka, Yawara Tajima, Toshiyuki Konosu, Noriko Takeda, Hiroshi Yasuda
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Abstract
Compounds of formula (I): ##STR1## in which: Ar is optionally substituted phenyl; is R.sup.1 is alkyl; R.sup.2 is substituted alkyl, substituted cycloalkyl R.sup.2 or optionally substituted heterocyclic; and n is 0, 1 or 2; and pharmaceutically acceptable salts and esters thereof have valuable anti-fungal properties and can be used for pharmaceutical and veterinary treatment. Methods of preparing these compounds are also provided.
Claims9
A compound selected from the group consisting of 2-(4-chlorophenyl)-3-[(3-thietanyl)-sulfinyl]-1-(1H-1,2,4-triazol-1-yl)-2- butanol, 2-(2,4-dichlorophenyl)-3-[(3-oxetanyl)-thio]-1-(1H,1,2,4-triazol-1-yl)-2-b utanol, 2-(2,4-difluorophenyl)-3-[(3-thietanyl)-thio]-(1H-1,2,4-triazol-1-yl)-2-bu tanol, 2-(2,4-difluorophenyl)-3-[(S-oxothietan-3-yl)thio]-1-(1H-1,2,4-triazol-1-y l)-2-butanol, 2-(2,4-difluorophenyl)-3-[(S,S-dioxo-thietan-3-yl)thiol]-1-(1H-1,2,4-triaz ol-1-yl)-2-butanol, 2-(2,4-difluorophenyl)-3-(oxetan-3-ylthio)-1-(1H-1,2,4-triazol-1-yl)-2-but anol, and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.