Thiazolidinedione derivatives, their production and use
AssigneeTakeda Chemical Industries, Ltd.
InventorsTakashi Sohda, Hitoshi Ikeda, Sachiko Imai, Yu Momose
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Abstract
The object of the present invention is to provide a new thiazolidinedione derivative exhibiting excellent hypoglycemic and hypolipidemic action. Thiazolidinedione derivative represented by the general formula: ##STR1## wherein n represents an integer from 1 to 3; A represents an aromatic 5-membered heterocyclic ring residue which has at least one nitrogen atom as a ring component atom, which is bound via a carbon atom adjacent to the nitrogen atom and which may be substituted; .cndot..cndot..cndot..cndot..cndot..cndot..cndot..cndot. is a single bond or a double bond, or pharmacologically acceptable salt thereof, is novel, and shows excellent hypoglycemic and hypolipidemic action.
Claims6
A thiazolidinedione compound of the formula:
- ##STR82## wherein n is an integer of from 1 to 3,
- A is 1,2,3-triazol-4-yl or 1,2,4-triazol-3-yl, each of which may have 1 or more substituents, at any position on the ring thereof, selected from the group consisting of
- (1) an aliphatic hydrocarbon selected from the group consisting of alkyl of 1 to 8 carbon atoms, alkenyl having 2 to 8 carbon atoms and alkynyl having 2 to 8 carbon atoms,
- (2) an alicyclic hydrocarbon selected from the group consisting of cycloalkyl having 3 to 7 carbon atoms and cycloalkenyl having 5 to 7 carbon atoms,
- (3) an alicyclic-aliphatic hydrocarbon selected from the group consisting of cycloalkyl-alkyl of 4 to 9 carbon atoms, cycloalkyl-alkenyl of up to 9 carbon atoms, cycloalkyl-alkynyl of up to 9 carbon atoms, cycloalkenyl-alkyl of 4 to 9 carbon atoms, cycloalkenyl-alkenyl of up to 9 carbon atoms and cycloalkenyl-alkynyl of up to 9 carbon atoms,
- (4) phenylalkyl having 7 to 9 carbon atoms,
- (5) naphthylalkyl having 11 to 13 carbon atoms,
- (6) phenyl,
- (7) naphthyl,
- (8) thienyl,
- (9) furyl,
- (10) pyridyl,
- (11) thiazolyl,
- (12) oxazolyl,
- (13) piperidinyl,
- (14) pyrrolidinyl,
- (15) morpholinyl, and
- (16) tetrahydrofuryl, and
- each of the above substituents (2), (3), (13), (14), (15) and (16) may be substituted by 1 to 3 lower alkyl groups having 1 to 3 carbon atoms, and each of the above substituents (4), (5), (6), (7), (8), (9), (10), (11) and (12) may be substituted by 1 to 4 substituents selected from the group consisting of halogen, hydroxy, cyano, trifluoromethyl, lower alkoxy having 1 to 4 carbon atoms, lower alkyl having 1 to 4 carbon atoms, lower alkoxycarbonyl having 2 to 4 carbon atoms and lower alkylthio having 1 to 3 carbon atoms said substituents being present on the ring carbon atoms thereof, and .cndot..cndot..cndot..cndot..cndot..cndot..cndot..cndot. signifies a single bond or a double bond,
- or a pharmacologically acceptable salt thereof.
Dependencies are inferred from the claim text.