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US 5,489,598 AGranted
Cytoprotection utilizing aryltriazol-3-thiones
AssigneeWarner-Lambert Company
InventorsDavid T. Connor, Janet S. Plummer
Life of this patent
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Abstract
5-Aryltriazol-3-thiones are useful for inhibiting adhesion of Mac-1 and thereby providing cytoprotection for diseases mediated by Mac-1 adhesion.
Claims11
A method of inhibiting the adhesion of Mac-1 to endothelial cells, the method comprising administering to a subject having NSAID-induced gastritis, inflammatory bowel disease of ulcerative colitis a Mac-1 inhibiting amount of a compound of the formula ##STR3## wherein Ar is phenyl, pyridyl, naphthyl, and flurenyl, each of which may be mono-, di-, trisubstituted;
- and
- R.sub.4 is hydrogen, amino, hydroxy, alkyl, alkenyl, cycloalkyl, phenyl or substituted phenyl, benzyl or substituted benzyl, and the pharmaceutically acceptable addition salts thereof.
Dependencies are inferred from the claim text.