Phospholipid compounds and use therefor

A compound represented by the formula:

• ##STR15## and physiologically acceptable salts thereof, wherein R.sub.4 is a straight or branched, aliphatic hydrocarbon chain, which contains up to 20 carbon atoms in said hydrocarbon chain;
• Z is a dioxanyl group;
• and
• R.sub.5 is --H or C1 to C6 alkyl radical, wherein each R.sub.5 is independently selected.

A pharmaceutical composition having antitumor or immunomodulatory activity comprising a pharmaceutically acceptable carrier and an effective mount of a compound represented by the formula:

• ##STR16## and physiologically acceptable salts thereof, wherein R.sub.1 is a, straight or branched, aliphatic hydrocarbon chain, which contains up to 20 carbon atoms in said hydrocarbon chain, which may contain one or more carbon-carbon double bonds, and which may be substituted with one or more substituents selected from the group consisting of hydroxyl, C1 to C6 alkyl, C3 to C6 cycloalkyl, C1 to C6 alkoxy, C1 to C6 alkylthio and amino;
• Q is a C3 to C4 heterocycle containing at least two ring oxygen atoms as the only ring hetero atoms, wherein said heterocycle may be substituted with one or more C1 to C6 alkyl substituents;
• R.sub.2 is a methylene radical, which may be substituted with one or more C1 to C6 alkyl substituents;
• R.sub.3 is a C2 alkyl or alkenyl, which may be substituted with one or more C1 to C6 alkyl substituents;
• W is an ammonium group, wherein said ammonium group may be substituted one or more times with a C1 to C6 alkyl radical, or is a C3 to C7 heterocyclic amine having a nitrogen heteroatom which is bonded to the R.sub.3 group, wherein said heterocycle may be substituted with one or more substituents selected from the group consisting of a C1 to C6 alkyl, C3 to C6 cycloalkyl, C1 to C6 alkoxy, C1 to C6 alkoxycarbonyl, and C1 to C6 alkylthio.

A pharmaceutical composition having antitumor or immunomodulatory activity comprising a pharmaceutically acceptable carrier and an effective amount of a compound represented by the formula:

• ##STR17## and physiologically acceptable salts thereof, wherein R.sub.4 is a straight or branched, aliphatic hydrocarbon chain, which contains up to 20 carbon atoms in said hydrocarbon chain;
• Z is a dioxanyl group;
• and
• R.sub.5 is --H or C1 to C6 alkyl radical, wherein each R.sub.5 is independently selected.