Back to results
US 5,489,579 AGranted
Potentation of NMDA antagonists
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsIan A. McDonald, Bruce M. Baron
Life of this patent
Estimating the term…
Abstract
The present invention is directed to a method for poteniating the therapeutic effects of selected NMDA antagonists.
Claims4
A pharmaceutical composition comprising:
- 1) a compound of the formula:
- ##STR3## in which E is represented by hydrogen, C.sub.1-4 alkyl, or --CF.sub.3 ;
- A is represented by a methylene or a trimethylene bridging group;
- and E.sub.1 is represented by hydrogen, C.sub.1-4 alkyl, cycloalkyl, trialkylamino, alkylphenyl, phenyl, or substituted phenyl, or a pharmaceutically acceptable salt thereof, which is present in an amount sufficient to antagonize the effects which excitatory amino acids have upon the NMDA receptor complex;
- 2) probenecid, which is present in an amount sufficient to potentiate said compound, and;
- 3) said compound and said probenecid are in admixture together with a pharmaceutical carrier.
3 more elements
A method for antagonizing the effects of excitatory amino acids upon the NMDA receptor complex comprising administering to a patient in need thereof:
- 1) a compound of the formula:
- ##STR4## in which E represented by hydrogen, C.sub.1-4 alkyl, or --CF.sub.3 ;
- A is represented by a methylene or a trimethylene bridging group;
- and E.sub.1 is represented by hydrogen, C.sub.1-4 alkyl, cycloalkyl, trialkylamino, alkylphenyl, phenyl, or substituted phenyl, or a pharmaceutically acceptable salt thereof, in an amount sufficient to antagonize the effects which excitatory amino acids have upon the NMDA receptor complex;
- and,
- 2) probenecid, in an amount sufficient to potentiate said antagonistic effects.
3 more elements
Dependencies are inferred from the claim text.