Chimeric protein that has a human Rho motif and deoxyribonuclease activity
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsMichael A. Resnick, Edward L. Perkins, Terry Chow
Life of this patent
Estimating the term…
Abstract
The present invention relates, in general, to endo-exonucleases. In particular, the present invention relates to DNA segments encoding for a polypeptide having an amino acid sequence corresponding to mammalian endo-exonuclease, a polypeptide having an amino acid sequence corresponding to mammalian endo-exonuclease, antibodies to mammalian endo-exonuclease, a recombinant DNA molecule, mutant cells substantially lacking endo-exonuclease activity, a cell containing mammalian endo-exonuclease, and methods of producing and using the polypeptide, DNA segment and mutants.
Claims12
An isolated primate endo-exonuclease.
An isolated mammalian endo-exonuclease having greater activity in the 5'.fwdarw.3' direction than in the 3'.fwdarw.5' direction.
An isolated mammalian endo-exonuclease having exonuclease activity on double-stranded polynucleotides and endonuclease activity on single-stranded polynucleotides.
An isolated multi-domain protein with N-terminal homology to the rho oncogene and endogenous nuclease activity wherein said protein is derived from a primate.
Dependencies are inferred from the claim text.