Rice flour-based oral rehydration solution
AssigneeAbbott Laboratories
InventorsLouis I. Ndife, Paul S. Anloague, Rosa C. B. Beach, Michelle M. B. Rushlow, Michael J. Neylan
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Abstract
A method for producing an improved rice flour-based oral rehydration solution using the enzymes cellulase and protease is disclosed. The oral rehydration solution of the invention has low viscosity, low osmolality, and can be ingested through the nipple of a bottle. The oral rehydration product can also be dried into powder form before packaging and reconstituted at the time of use. The product is designed to treat individuals with severe diarrhea brought about by cholera or other causes.
Claims17
A process for producing an oral rehydration solution containing electrolytes and rice flour comprising the steps of:
- (a) adding the rice flour to water while agitating to produce a rice slurry;
- (b) gelatinizing the rice slurry by heating;
- (c) cooling the slurry sufficiently to permit enzymatic hydrolysis;
- (d) adding the enzymes cellulase and protease to the slurry and allowing enzymatic digestion to occur for a period of time sufficient to permit hydrolysis of the rice flour;
- (e) inactivating the enzymes with heat and then cooling the slurry;
- (f) adding a stabilizer, minerals, and citric acid;
- (g) homogenizing the slurry;
- (i) standardizing the solution by adding water;
- and
- (j) terminally sterilizing the product.
Dependencies are inferred from the claim text.