Taste mask coatings for preparation of chewable pharmaceutical tablets
AssigneeMcNeil-PPC, Inc.
InventorsMichael R. Hoy, Edward J. Roche
Life of this patent
Estimating the term…
Abstract
Chewable tablets are made from a coated medicament wherein the coating comprises a mixture of dimethylaminoethyl methacrylate and neutral methacrylic acid ester and a cellulose ester, e.g. cellulose acetate, cellulose acetate butyrate, cellulose triacetate or a combination thereof and optionally polyvinyl pyrrolidone, and a process for making such tablets and a method of providing taste masking and sustained releasing of medicaments utilizing such coatings.
Claims12
A chewable medicament tablet comprising a medicament composition coated with a taste masking effective amount of a polymer blend consisting essentially of from about 5 to about 95 weight percent by total weight of the polymer blend of dimethylaminoethyl methacrylate and neutral methacrylic acid ester and from about 5 to about 95 percent by total weight of the polymer blend of a polymer selected from the group consisting of cellulose acetate, cellulose triacetate or a combination thereof.
A process of preparing a chewable medicament tablet comprising the steps of:
- coating a medicament composition with a taste masking effective amount of polymer blend consisting essentially of about 5 to about 95 weight percent by total weight of the polymer blend of dimethylaminoethyl methacrylate and neutral methacrylic acid ester and about 5 to about 95 weight percent by total weight of the polymer blend of a polymer selected from the group consisting of cellulose acetate, cellulose triacetate and combinations thereof;
- and forming a chewable tablet by compressing the coated medicament composition in the presence of excipients.
A method for taste masking medicaments comprising coating a medicament composition with a taste masking effective amount of a polymer blend consisting essentially of from about 5 to about 95 weight percent by total weight of the polymer blend of dimethylaminoethyl methacrylate and neutral methacrylic acid ester and about 5 to about 95 weight percent by total weight of the polymer blend of a polymer selected from the group consisting of cellulose acetate, cellulose triacetate and combinations thereof.
Dependencies are inferred from the claim text.