Method for entrapment of active materials in chitosan
AssigneeRamot University Authority for Applied Research and Industrial Development Ltd.
InventorAmihay Freeman
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Abstract
Encapsulation of active materials in chitosan beads of uniform size and improved mechanical and chemical stability. The active material is suspended in an acidic aqueous solution of a chitosan having a molecular weight of less than 250,000, the suspension is added dropwise to a crosslinking solution of diphosphate and glyoxal hydrate and the resulting beads are cured. It is possible to coat the active material with oil prior to suspension.
Claims16
A process for the encapsulation of at least one active material in chitosan beads, comprising adding dropwise, a suspension of at least one active material in an acidic aqueous solution containing from about 2% to about 3% (w/v) of chitosan of molecular weight less than 250,000, to a crosslinking solution containing a 0.5-2% (w/v) of diphosphate buffer and 1-4% (w/v) glyoxal hydrate, whereby chitosan beads are formed with said at least one active material entrapped therein, and the formed beads are cured in said crosslinking solution.
Dependencies are inferred from the claim text.