Hydrogels capable of supporting cell growth
AssigneeTrustees of Boston University
InventorsCarl Franzblau, Barbara A. Faris, Linda Civerchia-Perez
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Abstract
A method of growing anchorage-dependent cells is disclosed in which a substrate includes a hydrogel is employed. The hydrogel is formed from an aqueous solution gelled with a crosslinked polymer of a hydrophilic monomer and includes a macromolecule capable of supporting cell growth.
Claims12
A wound dressing comprising a single layer hydrogel formed from an aqueous solution gelled with a crosslinked polymer of a hydrophilic monomer and having incorporated within said hydrogel a cell growth-supporting macromolecule in an amount sufficient to render the hydrogel capable of supporting growth of anchorage-dependent mammalian cells.
A wound dressing comprising a single-layer hydrogel formed from an aqueous solution gelled with a crosslinked polymer of a hydrophilic monomer and having incorporated within said single-layer hydrogel a cell growth-supporting macromolecule in an amount sufficient to render the single-layer hydrogel capable of supporting growth of anchorage-dependent mammalian cells.
A wound dressing comprising a one layer hydrogel having incorporated therein a cell growth-supporting macromolecule, the hydrogel formed by a method comprising the steps of:
- a) combining a polymer of a hydrophilic monomer and the cell-growth supporting macromolecule in an aqueous solution;
- and
- b) crosslinking the polymer to gel the aqueous solution, thereby forming a hydrogel, wherein the macromolecule is incorporated within the hydrogel.
A wound dressing comprising a one-layer hydrogel having incorporated therein a cell growth-supporting macromolecule, the one-layer hydrogel formed by a method comprising the steps of:
- a) combining a polymer of a hydrophilic monomer and the cell-growth supporting macromolecule in an aqueous solution;
- and
- b) crosslinking the polymer to gel the aqueous solution, thereby forming the one-layer hydrogel, wherein the macromolecule is incorporated within the one-layer hydrogel.
A wound dressing which is a one layer hydrogel formed from an aqueous solution gelled with a crosslinked polymer of a hydrophilic monomer and having incorporated within said hydrogel a cell growth-supporting macromolecule in an amount sufficient to render the hydrogel capable of supporting growth of anchorage-dependent mammalian cells.
A wound dressing which includes a one-layer hydrogel formed from an aqueous solution gelled with a crosslinked polymer of a hydrophilic monomer and having incorporated within said one-layer hydrogel a cell growth-supporting macromolecule in an amount sufficient to render the one-layer hydrogel capable of supporting growth of anchorage-dependent mammalian cells.
Dependencies are inferred from the claim text.