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US 5,488,116 AGranted
Total synthesis of taxol and analogues thereof
AssigneeSloan-Kettering Institute for Cancer Research
InventorsSamuel J. Danishefsky, William G. Bornmann, Yves Queneau, Thomas V. Magee, Walter J. Krol, John J. Masters, David K. Jung
Life of this patent
Estimating the term…
Abstract
The present invention provides three basic routes for the total synthesis of taxol having the structure: ##STR1## The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogues of taxol and nortaxol.
Claims2
A compound having the structure:
- ##STR323## wherein X is CH.sub.2 or O;
- wherein Y is O;
- wherein R.sup.1 is a linear or branched chain alkyl or arylalkyl group, or an aryl group;
- wherein R.sup.2 is a trimethylsilyl, triethylsilyl, or t-butyldimethylsilyl group, or a linear or branched chain alkyl group;
- wherein R.sup.3 is a linear or branched chain alkyl or alkylaryl group, or an aryl group;
- and wherein R.sup.4 is H, a linear or branched chain alkyloxyalkyl group, a linear or branched chain alkyl or arylalkyl group, or an aryl group.
3 more elements
A compound having the structure:
- ##STR324## wherein Y is O;
- wherein R.sup.1 is a linear or branched chain alkyl or arylalkyl group, or an aryl group;
- wherein R.sup.2 is a trimethylsilyl, triethylsilyl, or t-butyldimethylsilyl group, or a linear or branched chain alkyl group;
- wherein R.sup.3 is a linear or branched chain alkyl or alkylaryl group, or an aryl group;
- wherein R.sup.4 is H, a linear or branched chain alkyloxyalkyl group, a linear or branched chain alkyl or arylalkyl group, or an aryl group;
- and wherein R.sup.5 is a linear or branched chain acyl group, or an aroyl group.
3 more elements
Dependencies are inferred from the claim text.