Pharmaceutical composition comprising BPI proteins
AssigneeXoma Corporation
InventorsWeldon C. McGregor, James Stubstad, C. Paul Chang
Life of this patent
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Abstract
Bactericidal/permeability increasing (BPI) polypeptide pharmaceutical compositions having improved stability and resistance to aggregation, particle formation and precipitation comprising the polypeptide pharmaceutical and poloxamer surfactants alone, or in combination with polysorbate suractants. Preferred BPI polypeptides stabilized are bactericidal/permeability increasing (BPI) protein, biologically active fragments of BPI, and biologically active analogs of BPI.
Claims6
A pharmaceutical composition comprising a bactericidal/permeability-increasing (BPI) protein or BPI fragment thereof, or a BPI analog of said bactericidal/permeability-increasing protein or BPI fragment, in combination with a polyoxypropylene-polyoxyethylene block copolymer (poloxamer) surfactant in a solubilizing/stabilizing concentration.
A pharmaceutical composition comprising a bactericidal/permeability-increasing (BPI) protein or BPI fragment thereof, or a BPI analog of said bactericidal/permeability-increasing protein or BPI fragment, in combination with a polyoxypropylene-polyoxyethylene block copolymer (poloxamer) surfactant for synergistically solubilizing/stabilizing said composition and a polyoxyethylene sorbitan fatty acid ester (polysorbate) surfactant.
Dependencies are inferred from the claim text.