Cellulosic polymer, blood-treating device, and process for producing the same

A process for producing a blood-treating device comprising the steps of:

• forming a hollow fiber membrane comprising a cellulosic polymer;
• assembling a blood treating device comprising said hollow fiber membrane;
• contacting at least a portion of said hollow fiber membrane which contacts the blood with an aqueous alkali solution and then with an aqueous solution containing a compound of the formula:
• R.sup.1 CH=CR.sup.2 X--(CH.sub.2).sub.n -Y (II)
• to modify a DA (phosphorous) improving number of the hydroxyl groups of said portion of cellulosic polymer which contacts the blood, according to the formula ##STR18## wherein R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom or a C.sub.1 to C.sub.5 alkyl group, X is a member selected from the group consisting of ##STR19## wherein R.sup.8 is a member selected from the group consisting of a hydrogen atom, a C.sub.1 to C.sub.5 alkyl group, a C.sub.3 to C.sub.6 cycloalkyl group and a C.sub.6 to C.sub.10 aryl group, and Y is ##STR20## wherein R.sup.3 and R.sup.4 may be the same or different and each represents a member selected from the group consisting of a hydrogen atom, a C.sub.1 to C.sub.5 alkyl group, a C.sub.3 to C.sub.6 cycloalkyl group, or Y is ##STR21## wherein R.sup.5, R.sup.6 and R.sup.7 may be the same or different and each represents a member selected from the group consisting of a hydrogen atom, a C.sub.1 to C.sub.5 alkyl group, a C.sub.3 to C.sub.6 cycloalkyl group and a C.sub.6 to C.sub.10 aryl group, and n is an integer from 2 to 10.

A process for producing a blood-treating device comprising the steps of:

• forming a hollow fiber membrane comprising a cellulosic polymer;
• contacting at least a portion of said hollow fiber membrane which contacts the blood with an aqueous alkali solution and then with an aqueous solution containing a compound of the formula ##STR22## to modify a DA (phosphorus) improving number of hydroxyl groups of said portion of said cellulosic polymer which contacts the blood, as represented by the formula ##STR23## wherein R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom or C.sub.1 to C.sub.5 alkyl group, X is a member selected form the groups consisting of ##STR24## R.sup.8 is a member selected from the group consisting of a hydrogen atom, a C.sub.1 to C.sub.5 alkyl group, a C.sub.3 to C.sub.6 cycloalkyl group and a C.sub.6 to C.sub.10 aryl group, and Y is ##STR25## wherein R.sup.3 and R.sup.4 may be the same or different and each represents a member selected from the group consisting of a hydrogen atom, a C.sub.1 to C.sub.5 alkyl group and a C.sub.3 to C.sub.6 cycloalkyl group, or Y is ##STR26## wherein R.sup.5, R.sup.6 and R.sup.7 may be the same or different and each represents a member selected form the group consisting of a hydrogen atom, a C.sub.1 to C.sub.5 alkyl group, a C.sub.3 to C.sub.6 cycloalkyl group and a C.sub.6 to C.sub.10 aryl group, and n is an integer from 2 to 10, and assembling a hollow fiber type blood-treating device using said hollow fiber membrane.