Method for producing aclacinomycins A, B, Y using Strepomyces lavendofoliae DKRS

A method of selectively producing aclacinomycin Y, comprising

• growing a pure cell culture of S. lavendosoliae DKRS having the ATCC Accession No. KCTC 0092BP in an expression medium at a temperature of about 28.degree. to 30.degree. C. and a pH of about 6.8 to 7.5 under aerobic conditions;
• allowing the formation of aclacinomycins A, B and Y in the cell and the medium;
• adjusting the pH of the medium to about 4.4;
• and
• separating aclacinomycin Y from the medium and the cells.

A method of selectively producing aclacinomycin A, comprising;

• growing a pure cell culture of S. lavendosoliae DKRS having the ATCC Accession No. KCTC 0092BP in an expression medium at a temperature of about 28.degree. to 30.degree. C. and a pH of about 6.8 to 7.5 under aerobic conditions;
• allowing the formation of aclacinomycins A, B and Y in the cell and the medium;
• adjusting the pH of the medium to about 4.6;
• and
• separating aclacinomycin A from the medium and the cells.