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US 5,482,936 AGranted
Imidazo[4,5-C]quinoline amines
AssigneeMinnesota Mining and Manufacturing Company
InventorKyle J. Lindstrom
Life of this patent
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Abstract
Compounds and pharmaceutically acceptable salts thereof formally derived by bridging the 1- and 2-positions of 1H-imidazo[4,5-c]quinolin-4-amines. Also, methods of using such compounds and pharmaceutical formulations containing such compounds. Said compounds are useful to induce interferon biosynthesis in an animal.
Claims12
A compound of Formula II ##STR7## wherein Z is selected from the group consisting of:
- --(CH.sub.2).sub.n -- wherein n is 1 to 4;
- --(CH.sub.2).sub.a --C(R.sub.1 R.sub.2)(CH.sub.2).sub.b --, wherein a and b are integers and a+b is 0 to 3, R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms, and R.sub.2 is selected from the group consisting of alkyl of 1 to 4 carbon atoms, hydroxy, --OR.sub.3 wherein R.sub.3 is alkyl of 1 to 4 carbon atoms, and --NR.sub.4 R'.sub.4 wherein R.sub.4 and R'.sub.4 are independently hydrogen or alkyl of 1 to 4 carbon atoms;
- and
- --(CH.sub.2).sub.a --(Y)--(CH.sub.2).sub.b -- wherein a and b are integers and a+b is 0 to 3, and Y is O, S, or --NR.sub.5 -- wherein R.sub.5 is hydrogen or alkyl of 1 to 4 carbon atoms;
- and wherein q is 0 or 1 and R is selected from the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, and halogen,
- and pharmaceutically acceptable salts thereof.
3 more elements
Dependencies are inferred from the claim text.