# US 5,480,865 A · Nutritional composition

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- Number: US 5,480,865 A
- Document ID: US5480865A
- Status: Granted
- Kind: A
- Application number: 08/202,065
- Filed: 1994-02-25
- Granted: 1996-01-02
- Earliest claimed: 1994-02-25
- Assignees: Parkinson's Charitable Trust
- Inventors: Douglas J. Kingham
- Web page: https://patentgrep.com/patent/US5480865A

## CPC

- A23G 1/44: containing peptides or proteins (containing dairy products A23G1/46)
- A23G 3/44: containing peptides or proteins (containing dairy products A23G3/46)
- A23L 9/12: {Ready-to-eat liquid or semi-liquid desserts, e.g. puddings, not to be mixed with liquids, e.g. water, milk}
- A23L 33/115: Fatty acids or derivatives thereof; Fats or oils
- A23L 33/175: Amino acids
- A23L 33/19: Dairy proteins
- A23G: COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)

## Abstract

Nutritional compositions are provided for the management of protein intake which have a carbohydrate to protein ratio of at least about 3.5:1 and a ratio of one group of amino acids to another group of amino acids of from about 3:1 to about 6.5:1 where the one group consists of glycine, serine, lysine, alanine, aspartic acid, glutamic acid, proline, arginine and hydroxyproline and the other group of amino acids consists of phenylalanine, tryptophan, threonine, valine, isoleucine, histidine, leucine, tyrosine and methionine. The compositions provide minimized interference with large neutral amino acid (LNAA) type therapeutic agents.

## Claims

### Claim 1

A nutritional composition for the management of protein intake which comprises a first weight-to-weight ratio of carbohydrate to protein of from about 3.5:1 to about 12:1, and a second A:B weight-to-weight ratio of from about 3:1 to about 6.5:1 wherein:
A is the group of amino acids consisting of glycine, serine, lysine, alanine, aspartic acid, glutamic acid, proline, arginine and hydroxyproline; and
B is the group of amino acids consisting of phenylalanine, tryptophan, threonine, valine, isoleucine, histidine, leucine, tyrosine and methionine.

### Claim 2 (depends on 1)

A composition according to claim 1 wherein said first ratio is from about 7:1 to about 12: 1.

### Claim 3 (depends on 2)

A composition according to claim 2 wherein said first ratio is from about 7:1 to about 8: 1.

### Claim 4 (depends on 3)

A composition according to claim 3 wherein said first ratio is about 7.5: 1.

### Claim 5 (depends on 1)

A composition according to claim 1 wherein said second A:B ratio is from about 4:1 to about 5:1.

### Claim 6 (depends on 1)

A composition according to claim 1 wherein said second A:B ratio is about 4.5:1.

### Claim 7 (depends on 2, 3, 4)

A composition according to claim 2, 3 or 4 wherein said second A:B ratio is from about 4:1 to about 5:1.

### Claim 8 (depends on 2, 3, 4)

A composition according to claim 2, 3 or 4 wherein said second A:B ratio is about 4.5:1.

### Claim 9 (depends on 1, 2, 3, 4, 5, 6)

A composition according to any of claims 1-6 further comprising a third A*:B weight-to-weight ratio of from about 1.5:1 to about 4.5:1 wherein:
A* is the group of amino acids consisting of glycine, glutamic acid, proline and hydroxyproline; and
B is the group of amino acids consisting of phenylalanine, tryptophan, threonine, valine, isoleucine, histidine, leucine, tyrosine and methionine.

### Claim 10 (depends on 9)

A composition according to claim 9 wherein said third A*:B ratio is from about 2.5:1 to about 3.5:1.

### Claim 11 (depends on 10)

A composition according to claim 10 wherein said third A*:B ratio is about 3:1.

### Claim 12

A method of managing protein intake comprising the administration of a composition which comprises a first weight-to-weight ratio of carbohydrate to protein of from about 3.5:1 to about 12:1 and a second A:B weight-to-weight ratio of from about 3:1 to about 6.5:1 wherein:
A is the group of amino acids consisting of glycine, serine, lysine, alanine, aspartic acid, glutamic acid, proline, arginine and hydroxyproline; and
B is the group of amino acids consisting of phenylalanine, tryptophan, threonine, valine, isoleucine, histidine, leucine, tyrosine and methionine.

### Claim 13 (depends on 12)

A method according to claim 12 wherein said composition additionally comprises a third A*:B weight-to-weight ratio of from about 1.5:1 to about 4.5:1 wherein:
A* is the group of amino acids consisting of glycine, glutamic acid, proline and hydroxyproline; and
B is the group of amino acids consisting of phenylalanine, tryptophan, threonine, valine, isoleucine, histidine, leucine, tyrosine and methionine.

### Claim 14 (depends on 13)

A method according to claim 13 wherein said first ratio is from about 7:1 to about 12:1.

### Claim 15 (depends on 14)

A method according to claim 14 wherein said first ratio is from about 7:1 to about 8:1.

### Claim 16 (depends on 15)

A method according to claim 15 wherein said first ratio is about 7.5:1.

### Claim 17 (depends on 12)

A method according to claim 12 wherein said second A:B ratio is from about 4:1 to about 5:1.

### Claim 18 (depends on 12)

A method according to claim 12 wherein said second A:B ratio is about 4.5:1.

### Claim 19 (depends on 14, 15, 16)

A method according to claim 14, 15 or 16 wherein said second A:B ratio is from about 4:1 to about 5:1.

### Claim 20 (depends on 14, 15, 16)

A method according to claim 14, 15 or 16 wherein said second A:B ratio is about 4.5:1.

### Claim 21 (depends on 13)

A method according to claim 13 wherein said third A*:B ratio is from about 2.5:1 to about 3.5:1.

### Claim 22 (depends on 13)

A method according to claim 13 wherein said third A*:B ratio is about 3:1.