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US 5,478,955 AGranted
26,27-dimethylene-1.alpha.,25-dihydroxyvitamin D.sub.2 and 26, 27-dimethylene-24-epi-1.alpha., 25-dihydroxyvitamin D.sub.2 and methods for preparing same
AssigneeWisconsin Alumni Research Foundation
InventorsHector F. DeLuca, Naoshi Nakagawa
Life of this patent
Estimating the term…
Abstract
The invention is drawn to cholesterol derivatives in which a cyclopentane ring has been introduced onto the 25-carbon of the side chain and to 24-epimers of these compounds. The compounds are useful intermediates in the production of 26,27-dimethylene-1.alpha.,25-dihydroxyvitamin D.sub.2 and 26,27-dimethylene-24-epi-1.alpha.,25-dihydroxyvitamin D.sub.2. These vitamin D derivatives are useful for the treatment of diseases such as osteoporosis.
Claims2
A compound having the formula
- where R.sup.1 and R.sup.2 are hydrogen or methyl with the proviso that when R.sup.1 is hydrogen R.sup.2 cannot be hydrogen and when R.sup.1 is methyl R.sup.2 cannot be methyl, and R.sup.3, R.sup.4 and R.sup.5 are hydrogen or a hydroxy-protecting group.
Dependencies are inferred from the claim text.