Process for the preparation of 2-amino-5-aminomethyl-pyridine
AssigneeBayer Aktiengesellschaft
InventorHelmut Kraus
Life of this patent
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Abstract
2-Amino-5-aminomethyl-pyridine, of the formula ##STR1## can be prepared by reacting substituted methylene-glutaconic acid dinitrile of the formula ##STR2## having the meaning of R.sup.1 as given in the general description, at from 50.degree. to 200.degree. C., initially with from 3 to 20 mol of ammonia and then, in the presence of a hydrogenation catalyst, with hydrogen. The hydrogen is present an a partial pressure of from 10 to 250 bar. The reaction can be carried out with or without solvent.
Claims11
A process for the preparation of 2-amino-5-aminomethyl-pyridine, of the formula ##STR6## wherein a substituted methylene-glutaconic acid dinitrile of the formula ##STR7## in which R.sup.1 represents --OR.sup.2 or --N(R.sup.2,R.sup.3),
- in which
- R.sup.2 and R.sup.3, independently of one another, present straight-chain or branched C.sub.1 -C.sub.8 -alkyl, C.sub.3 -C.sub.8 -alkenyl, C.sub.2 -C.sub.8 -alkoxyalkyl, C.sub.4 -C.sub.8 -alkoxyalkenyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.6 -C.sub.12 -aryl, C.sub.7 -C.sub.10 -aralkyl or R.sup.2 and R.sup.3, together with the N atom on which they are substituents, form a 5- to 6-membered ring wherein said rings are pyrrolidine, piperazine, morpholine, or piperidine wherein said piperazine, piperidine, morpholine and pyrrolidine moieties are optionally substituted on the N atom by C.sub.1 -C.sub.4 -alkyl or by hydroxy-C.sub.1 -C.sub.4 -alkyl, is initially reacted at a temperature from 50.degree. to 200.degree. C., with from 3 to 200 mol of ammonia and then reacted in the presence of a hydrogenation catalyst containing Ni, Co, Pd, Pt and Rh with hydrogen which is present at a H.sub.2 partial pressure of from 10 to 250 bar, optionally in the presence of a solvent.
Dependencies are inferred from the claim text.