Cyclic urea derivatives and pharmaceutical compositions containing these compounds

A cyclic urea derivative of formula ##STR24## wherein Y is a --CR.sub.c .dbd.N-- or --N.dbd.CR.sub.c -group, wherein R.sub.c is a hydrogen atom, and C.sub.1-4 -alkyl, trifluoromethyl or phenyl group;

• one of the groups R.sub.a or R.sub.b is a group of formula
• A--B--C--
• wherein
• A is a straight-chained or branched C.sub.1-4 -aminoalkyl group, an amino, amidino or guanidino group, wherein in each of the above-mentioned groups, at one of the nitrogen atoms, one hydrogen atom may be replaced by a C.sub.1-4 -alkyl group or an alkoxycarbonyl group having a total of 2 to 5 carbon atoms or by a benzyloxycarbonyl group;
• B is a bond;
• a phenylene group which may be substituted by one or two C.sub.1-4 -alkyl groups, by a fluorine, chlorine, bromine or iodine atom, by a trifluoromethyl, C.sub.1-4 -alkoxy, C.sub.1-4 -alkylsulphenyl, C.sub.1-4 -alkylsulphinyl, C.sub.1-4 -alkylsulphonyl, nitro, amino, acetylamino, benzoylamino or methanesulphonylamino group, or a C.sub.3-6 -cycloalkylene group;
• C is an ethylene group optionally substituted by a hydroxy group,
• a methylenecarbonyl group linked to the group B via the carbonyl group, or
• a phenylene group which may be substituted by one or two C.sub.1-4 -alkyl groups, by a fluorine, chlorine, bromine or iodine atom, by a trifluoromethyl, C.sub.1-4 -alkoxy, C.sub.1-4 -alkylsulphenyl, C.sub.1-4 -alkylsulphinyl, C.sub.1-4 -alkylsulphonyl, nitro, amino, acetylamino, benzoylamino or methanesulphonylamino group;
• the other of the groups R.sub.a or R.sub.b is a group of formula
• F--E--D--
• wherein
• D is a C.sub.1-4 -alkylene group,
• a phenylene group which may be substituted by one or two C.sub.1-4 -alkyl groups, by a fluorine, chlorine, bromine or iodine atom, by a trifluoromethyl, C.sub.1-4 -alkoxy, C.sub.1-4 -alkylsulphenyl, C.sub.1-4 -alkylsulphinyl, C.sub.1-4 -alkylsulphonyl, carboxymethoxy, methoxycarbonylmethoxy, nitro, amino, acetylamino, benzoylamino or methanesulphonylamino group,
• a cyclohexylene group optionally substituted by one or two methyl groups, or
• a 1,4-piperidinylene group, which is linked via the 1-position to the optionally substituted C.sub.1-4 -alkylene group of E;
• E is a bond;
• a C.sub.1-4 -alkylene group optionally substituted by one or two methyl groups or by a hydroxy, methoxy, amino, methylamino, dimethylamino, dibenzylamino, carboxymethyl or methoxycarbonylmethyl group,
• a C.sub.2-3 -alkenylene group;
• a phenylene group which may be substituted by one or two C.sub.1-4 -alkyl groups, by a fluorine, chlorine, bromine or iodine atom, by a trifluoromethyl or C.sub.1-4 -alkoxy group, or
• a C.sub.1-2 -alkylene group linked to group D by the group W', wherein W' is an oxygen or sulphur atom, a sulphinyl, sulphonyl, --NH--, --N(C.sub.1-4 -alkyl)-, --N(COC.sub.1-4 -alkyl)-, --N(SO.sub.2 C.sub.1-4 -alkyl)-, aminocarbonyl or carbonylamino group;
• and
• F is a carbonyl group substituted by a hydroxy group, by a C.sub.1-6 -alkoxy group or by a phenylalkoxy group having 1 or 2 carbon atoms in the alkoxy part, wherein if A is an amino or aminoalkyl group optionally benzyloxycarbonylated at the nitrogen atom, the shortest distance between the nitrogen atom of this group and group F is at least 10 bonds;
• the tautomers, the stereoisomers, including the mixtures thereof, or the addition salts thereof.