Nitrogenous bicyclic derivatives substituted with benzyl

A method of inhibiting the effects of angiotensin II in warm-blooded animals comprising administering to warm-blooded animals an amount sufficient to inhibit angiotensin II effects of a compound of the formula ##STR60## wherein R.sub.2B and R.sub.3B are individually selected from the group consisting of

• a) hydrogen, halogen, hydroxyl, mercapto, cyano, nitro, sulfo, formyl, benzoyl, acyl of up to 12 carbon atoms, free, salified carboxy, carboxy esterified with a lower alkanol, cycloalkyl of 3 to 7 carbon atoms, acyloxy of up to 12 carbon atoms,
• b) alkyl, alkenyl, alkynyl, alkoxy and alkylthio of up to 6 carbon atoms,
• c) aryl, aralkyl, aralkenyl, aryloxy and arylthio with 1 to 6 alkyl and alkenyl carbon atoms, the aryl being a carbocyclic monocycle of 5 or 6 ring members, ##STR61## either R.sub.6B and R.sub.7B or R.sub.8B and R.sub.9B individually are selected from the group consisting of hydrogen, alkyl and alkenyl of up to 6 carbon atoms and optionally substituted by at least one halogen or hydroxyl, alkyl and alkenyl of 2 to 6 carbon atoms substituted by alkoxy of 1 to 6 carbon atoms, aryl and aralkyl with up to 6 alkyl carbon atoms, the aryl being a carbocyclic monocycle of 5 or 6 ring members and optionally substituted by at least one member of the group consisting of halogen, hydroxyl, cyano, trifluoromethyl, nitro, alkyl, alkenyl, alkoxy, alkylthio and acyl of up to 6 carbon atoms, free, salified carboxy, carboxy esterified with a lower alkanol, --(CH.sub.2).sub.m1 --S(0).sub.m2 --X--R.sub.14, m.sub.1 is an integer from 0 to 4 and m2 is an integer from 0 to 2 and either --X--R.sub.14 is --NH.sub.2,
• or X is selected from the group consisting of --NH--, --NH--CO--, --NH--CO--NH-- and a single bond and R.sub.14 is alkyl, alkenyl or aryl optionally substituted, or R.sub.6B and R.sub.7B or R.sub.8B and R.sub.9B form respectively with the nitrogen atom to which they are attached a carbocyclic monocycle of 5 or 6 ring members and optionally substituted by at least one member of the group consisting of halogen, hydroxyl, cyano, trifluoromethyl, nitro, alkyl, alkenyl, alkoxy, alkylthio and acyl of up to 6 carbon atoms, free, salified carboxy, and carboxy esterified with a lower alkanol
• or R.sub.8B and R.sub.9B individually are acyl of a carboxylic acid of up to 6 carbon atoms,
• e) --(CH.sub.2).sub.m1 --S(0).sub.m2 --X--R.sub.14 as defined above, A.sub.1B, A.sub.2B, A.sub.3B and A.sub.4B are such that two are nitrogen, another is methine substituted by R.sub.4c, and the last one is methine substituted by optionally substituted benzyl, R.sub.4c is selected from the group consisting of
• a) hydrogen, hydroxyl, cyano, benzoyl, acyl of up to 12 carbon atoms, free, salified carboxy, carboxy esterified with a lower alkanol cycloalkyl of 3 to 7 carbon atoms,
• b) alkyl, alkenyl, alkynyl, alkoxy or alkylthio of up to 6 carbon atoms and their non-toxic, pharmaceutically acceptable salts with acids and bases.