Ecteinascidins
AssigneeThe Board of Trustees of the University of Illinois
InventorsKenneth L. Rinehart, Ryuichi Sakai
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Abstract
Ecteinascidins (Et's), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma zenografts.
Claims4
The N.sup.12 -oxide of ecteinascidin 743, substantially free of any cellular debris of Ecteinascidia turbinata, which has the following structure:
- ##STR2## wherein R.sub.1 is OH and R.sub.2 is OCH.sub.3.
The 21-O-methyl-N.sup.12 -formyl derivative of ecteinascidin 729, substantially free of any cellular debris of Ecteinascidia turbinata, which has the following structure:
- ##STR3## wherein R.sub.1 is OCH.sub.3 and R.sub.2 is CHO.
The N.sup.12 -formyl derivative of ecteinascidin 729, which has the following structure:
- ##STR4## wherein R.sub.1 is OH and R.sub.2 is CHO.
The 21-cyano analog of ecteinascidin 729, which has the following structure:
- ##STR5## wherein R.sub.1 is cyano and R.sub.2 is H.
Dependencies are inferred from the claim text.