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US 5,478,923 AGranted
Class of low calorie protein sweeteners
AssigneesThe Regents of the University of California, Lucky, Ltd.
InventorsSung-Hou Kim, Joong M. Cho
Life of this patent
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Abstract
Single-chain analogs of the naturally occurring two-chain peptide monellin retain the sweetening properties of the natural protein and are stable under conditions which would otherwise destabilize the native peptide. A covalent linkage joins peptides corresponding to portions of the A and B chains of the naturally occurring protein.
Claims11
A single chain sweet proteinaceous compound, of the formula B-C-A,
- wherein B represents a peptide portion at least 90% homologous to residues 1-46 of the B chain of native monellin and modified only by conservative substitutions;
- C is a covalent bond or is a hydrophilic, physiologically acceptable covalent linker capable of providing a spacing length equivalent to a peptide of 1-10 amino acids selected so as to reside on the external portion of the molecule and not to disturb the native conformation;
- and
- A represents a peptide at least 90% homologous to residues 6-45 of the A chain of native monellin and modified only by conservation substitution.
1 more element
Dependencies are inferred from the claim text.