Method for disinfection using a 1,n-bis(N.sup.5 -trifluoromethyl-phenyl-N.sup.1 -biguanido)-alkane
AssigneesMitsubishi Materials Corporation, Yoshida Pharmaceutical Co., Ltd.
InventorsAkira Nishihara, Akihiro Nakamura, Tsunetoshi Honda, Michio Harada, Maki Takizawa
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Abstract
A novel disinfectant is disclosed. Said disinfectant is a compound 1,n-bis(N.sup.5 -m-, or p-trifluoromethyl-phenyl-N.sup.1 -biguanido)-C.sub.3 -C.sub.10 -alkane. The m-trifluoro-C.sub.6 derivative is a known compound. The compounds of the present invention exhibit germicidal effect against Pseudomonas aeruginosa, Proteus vulgaris and Alcaligenes faecalis at concentrations of 1/4-1/8 of the effective concentration for chlorhexidine. Against other microorganisms, the compounds are effective at the same level as chlorhexidine.
Claims12
A method for disinfecting hands and fingers, operation localities, and operation instruments from one or more bacteria species selected from the group consisting of Pseudomonas aeruginos, methicillin-resistant Staphylococcus aureus, Alcaligenes faecalis, Klebsiella pneumoniae, Proteus vulgaris and Pseudomonas cepacia, said method comprising using a solution of (i) a 1,n-bis(N.sup.5 -trifluoromethylphenyl-N.sup.1 -biguanido)-alkane represented by the formula:
- ##STR3## wherein n is an integer of 5 or 6 and the trifluoromethyl group is located at the m-position or p-position or (ii) a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.